Normative database of the serotonergic system in healthy subjects using multi-tracer PET

• Published in: NeuroImage (Orlando, Fla.) Vol. 63; no. 1; pp. 447 - 459
• Main Authors: Savli, Markus, Bauer, Andreas, Mitterhauser, Markus, Ding, Yu-Shin, Hahn, Andreas, Kroll, Tina, Neumeister, Alexander, Haeusler, Daniela, Ungersboeck, Johanna, Henry, Shannan, Isfahani, Sanaz Attaripour, Rattay, Frank, Wadsak, Wolfgang, Kasper, Siegfried, Lanzenberger, Rupert
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.10.2012; Elsevier Limited
• Subjects: 5‐HT1A; 5‐HT1B; 5‐HT2A; 5‐HTT; Adolescent; Adult; Alzheimer's disease; Brain - diagnostic imaging; Brain - metabolism; Databases, Factual - standards; Female; Humans; Male; Middle Aged; Pathophysiology; PET; Positron-Emission Tomography - methods; Positron-Emission Tomography - standards; Proteins; Receptors, Serotonin - analysis; Receptors, Serotonin - metabolism; Reference Values; Serotonergic Neurons - diagnostic imaging; Serotonergic Neurons - metabolism; Serotonin; Young Adult; 5‐HT2A; 5‐HTT; 5‐HT1A; Serotonin; Database; 5‐HT1B; PET

The highly diverse serotonergic system with at least 16 different receptor subtypes is implicated in the pathophysiology of most neuropsychiatric disorders including affective and anxiety disorders, obsessive compulsive disorder, post-traumatic stress disorder, eating disorders, sleep disturbance, a...