Salivary Chromogranin A: Useful and Quantitative Biochemical Marker of Affective State in Patients with Amyotrophic Lateral Sclerosis

• Published in: Internal Medicine Vol. 47; no. 21; pp. 1875 - 1879
• Main Authors: Obayashi, Konen, Sato, Kimiko, Shimazaki, Rie, Ishikawa, Tomoko, Goto, Katsumasa, Ueyama, Hidetsugu, Mori, Teruaki, Ando, Yukio, Kumamoto, Toshihide
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2008
• Subjects: 40-item ALS assessment questionnaire; affective state; Aged; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - complications; Amyotrophic Lateral Sclerosis - diagnosis; Amyotrophic Lateral Sclerosis - psychology; Biochemical markers; Biomarkers - chemistry; Chromogranin A - analysis; chromogranins; Emotional behavior; Emotions; Emotions - physiology; Female; Health Status Indicators; Humans; Inventories; Male; Middle Aged; Mood Disorders - complications; Mood Disorders - diagnosis; Mood Disorders - psychology; Quality of life; Quality of Life - psychology; Saliva - chemistry; salivary chromogranin A; Statistical analysis; vascular dementia

Objective To evaluate the affective state biochemically and quantitatively in amyotrophic lateral sclerosis (ALS) patients using salivary chromogranin A (CgA) measurement. Subjects and Methods Twelve moderate and 12 terminal ALS patients defined using the ALS Health State Scale were studied. The cor...