Hereditary breast cancer: new genetic developments, new therapeutic avenues

• Published in: Human genetics Vol. 124; no. 1; pp. 31 - 42
• Main Authors: Campeau, Philippe M., Foulkes, William D., Tischkowitz, Marc D.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.08.2008; Springer; Springer Nature B.V
• Subjects: Acid Anhydride Hydrolases; AMP-Activated Protein Kinase Kinases; Animals; Antigens, CD; Ataxia Telangiectasia Mutated Proteins; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - therapy; Cadherins - genetics; Cadherins - physiology; Cancer; Cell Cycle Proteins - genetics; Cell Cycle Proteins - physiology; Checkpoint Kinase 2; Classical genetics, quantitative genetics, hybrids; Development and progression; Disease susceptibility; DNA repair; DNA Repair Enzymes - genetics; DNA Repair Enzymes - physiology; DNA-Binding Proteins - genetics; DNA-Binding Proteins - physiology; Fanconi Anemia Complementation Group N Protein; Fanconi Anemia Complementation Group Proteins; Fundamental and applied biological sciences. Psychology; Gene Function; Genes; Genes, BRCA1 - physiology; Genes, BRCA2 - physiology; Genes, p53 - physiology; Genetic aspects; Genetic research; Genetics of eukaryotes. Biological and molecular evolution; Genetics, Medical - trends; Genomes; Genomics; Gynecology. Andrology. Obstetrics; Health aspects; Human; Human Genetics; Humans; Mammary gland diseases; Medical sciences; Metabolic Diseases; Molecular Medicine; Monosaccharides; Nuclear Proteins - genetics; Nuclear Proteins - physiology; Oncology, Experimental; Penetrance; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - physiology; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - physiology; Review Article; RNA Helicases - genetics; RNA Helicases - physiology; Sugars; Therapeutics - trends; Tumor proteins; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - physiology; Tumors; Fanconi Anemia; Breast Cancer Susceptibility; Breast Cancer; Hereditary Breast Cancer; Nijmegen Breakage Syndrome; Mammary gland diseases; Breast disease; Development; Genetics; Breast cancer; Malignant tumor; Hereditary; Cancer

Six genes confer a high risk for developing breast cancer ( BRCA1/2 , TP53 , PTEN , STK11 , CDH1 ). Both BRCA1 and BRCA2 have DNA repair functions, and BRCA1/2 deficient tumors are now being targeted by poly(ADP-ribose) polymerase inhibitors. Other genes conferring an increased risk for breast cance...