Vaccine-escape and fast-growing mutations in the United Kingdom, the United States, Singapore, Spain, India, and other COVID-19-devastated countries

• Published in: Genomics (San Diego, Calif.) Vol. 113; no. 4; pp. 2158 - 2170
• Main Authors: Wang, Rui, Chen, Jiahui, Gao, Kaifu, Wei, Guo-Wei
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2021
• Subjects: Angiotensin-Converting Enzyme 2 - genetics; antibodies; Antibody; Binding affinity; Brazil; California; COVID-19; COVID-19 - epidemiology; COVID-19 - genetics; COVID-19 - prevention & control; COVID-19 - virology; COVID-19 Vaccines - adverse effects; COVID-19 Vaccines - genetics; Deep learning; domain; genes; genetic analysis; genetic drift; genomics; Humans; India; Mexico; Mutation; natural selection; Original; peptidyl-dipeptidase A; Persistent homology; Protein Binding - genetics; Protein Interaction Maps - genetics; SARS-CoV-2; SARS-CoV-2 - genetics; SARS-CoV-2 - pathogenicity; Severe acute respiratory syndrome coronavirus 2; Singapore; South Africa; Spain; Spike Glycoprotein, Coronavirus - genetics; United Kingdom; Vaccine escape; vaccines; virulence; viruses; Brazil; Mexico; South Africa; United Kingdom; California; India; Spain; COVID-19; Vaccine escape; Deep learning; SARS-CoV-2; Persistent homology; Antibody; Mutation; Binding affinity

Recently, the SARS-CoV-2 variants from the United Kingdom (UK), South Africa, and Brazil have received much attention for their increased infectivity, potentially high virulence, and possible threats to existing vaccines and antibody therapies. The question remains if there are other more infectious...