Deubiquitination and Stabilization of PD-L1 by CSN5

• Published in: Cancer cell Vol. 30; no. 6; pp. 925 - 939
• Main Authors: Lim, Seung-Oe, Li, Chia-Wei, Xia, Weiya, Cha, Jong-Ho, Chan, Li-Chuan, Wu, Yun, Chang, Shih-Shin, Lin, Wan-Chi, Hsu, Jung-Mao, Hsu, Yi-Hsin, Kim, Taewan, Chang, Wei-Chao, Hsu, Jennifer L., Yamaguchi, Hirohito, Ding, Qingqing, Wang, Yan, Yang, Yi, Chen, Chung-Hsuan, Sahin, Aysegul A., Yu, Dihua, Hortobagyi, Gabriel N., Hung, Mien-Chie
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.12.2016
• Subjects: Animals; anti-CTLA4; B7-H1 Antigen - chemistry; B7-H1 Antigen - metabolism; Cell Line, Tumor; COP9 Signalosome Complex; CSN5; curcumin; Curcumin - pharmacology; deubiquitination; Female; Humans; Intracellular Signaling Peptides and Proteins - metabolism; Mice; Neoplasm Transplantation; Neoplasms - metabolism; NF-kappa B - metabolism; PD-L1; Peptide Hydrolases - metabolism; Protein Stability; TNF-α; Tumor Necrosis Factor-alpha - metabolism; Ubiquitination; anti-CTLA4; CSN5; PD-L1; deubiquitination; TNF-α; curcumin

Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillanc...