Deubiquitination and Stabilization of PD-L1 by CSN5

Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillanc...

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Published in	Cancer cell Vol. 30; no. 6; pp. 925 - 939
Main Authors	Lim, Seung-Oe, Li, Chia-Wei, Xia, Weiya, Cha, Jong-Ho, Chan, Li-Chuan, Wu, Yun, Chang, Shih-Shin, Lin, Wan-Chi, Hsu, Jung-Mao, Hsu, Yi-Hsin, Kim, Taewan, Chang, Wei-Chao, Hsu, Jennifer L., Yamaguchi, Hirohito, Ding, Qingqing, Wang, Yan, Yang, Yi, Chen, Chung-Hsuan, Sahin, Aysegul A., Yu, Dihua, Hortobagyi, Gabriel N., Hung, Mien-Chie
Format	Journal Article
Language	English
Published	United States Elsevier Inc 12.12.2016
Subjects	Animals anti-CTLA4 B7-H1 Antigen - chemistry B7-H1 Antigen - metabolism Cell Line, Tumor COP9 Signalosome Complex CSN5 curcumin Curcumin - pharmacology deubiquitination Female Humans Intracellular Signaling Peptides and Proteins - metabolism Mice Neoplasm Transplantation Neoplasms - metabolism NF-kappa B - metabolism PD-L1 Peptide Hydrolases - metabolism Protein Stability TNF-α Tumor Necrosis Factor-alpha - metabolism Ubiquitination anti-CTLA4 CSN5 PD-L1 deubiquitination TNF-α curcumin
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Abstract	Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization of programmed cell death-ligand 1 (PD-L1). We demonstrated that COP9 signalosome 5 (CSN5), induced by NF-κB p65, is required for TNF-α-mediated PD-L1 stabilization in cancer cells. CSN5 inhibits the ubiquitination and degradation of PD-L1. Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy. [Display omitted] •TNF-α stabilizes cancer cell PD-L1 in response to chronic inflammation•Activation of NF-κB by TNF-α induces CSN5 expression leading to PD-L1 stabilization•CSN5 enzyme activity controls T cell suppression via PD-L1 deubiquitination•Destabilization of PD-L1 by CSN5 inhibitor curcumin benefits anti-CTLA4 therapy Lim et al. show that inflammation increases PD-L1 expression in tumors through TNF-α-mediated activation of NF-κB, leading to transactivation of CSN5. CSN5 reduces PD-L1 ubiquitination and stabilizes it. Inhibition of CSN5 cooperates with anti-CTLA4 to enhance anti-tumor T cell function and reduce tumor growth.
AbstractList	Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization of programmed cell death-ligand 1 (PD-L1). We demonstrated that COP9 signalosome 5 (CSN5), induced by NF-κB p65, is required for TNF-α-mediated PD-L1 stabilization in cancer cells. CSN5 inhibits the ubiquitination and degradation of PD-L1. Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy. Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF- alpha ) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization of programmed cell death-ligand 1 (PD-L1). We demonstrated that COP9 signalosome 5 (CSN5), induced by NF- Kappa B p65, is required for TNF- alpha -mediated PD-L1 stabilization in cancer cells. CSN5 inhibits the ubiquitination and degradation of PD-L1. Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy. Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization of programmed cell death-ligand 1 (PD-L1). We demonstrated that COP9 signalosome 5 (CSN5), induced by NF-κB p65, is required for TNF-α-mediated PD-L1 stabilization in cancer cells. CSN5 inhibits the ubiquitination and degradation of PD-L1. Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy.Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization of programmed cell death-ligand 1 (PD-L1). We demonstrated that COP9 signalosome 5 (CSN5), induced by NF-κB p65, is required for TNF-α-mediated PD-L1 stabilization in cancer cells. CSN5 inhibits the ubiquitination and degradation of PD-L1. Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy. Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization of programmed cell death-ligand 1 (PD-L1). We demonstrated that COP9 signalosome 5 (CSN5), induced by NF-κB p65, is required for TNF-α-mediated PD-L1 stabilization in cancer cells. CSN5 inhibits the ubiquitination and degradation of PD-L1. Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy. Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization of programmed cell death-ligand 1 (PD-L1). We demonstrated that COP9 signalosome 5 (CSN5), induced by NF-κB p65, is required for TNF-α-mediated PD-L1 stabilization in cancer cells. CSN5 inhibits the ubiquitination and degradation of PD-L1. Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy. [Display omitted] •TNF-α stabilizes cancer cell PD-L1 in response to chronic inflammation•Activation of NF-κB by TNF-α induces CSN5 expression leading to PD-L1 stabilization•CSN5 enzyme activity controls T cell suppression via PD-L1 deubiquitination•Destabilization of PD-L1 by CSN5 inhibitor curcumin benefits anti-CTLA4 therapy Lim et al. show that inflammation increases PD-L1 expression in tumors through TNF-α-mediated activation of NF-κB, leading to transactivation of CSN5. CSN5 reduces PD-L1 ubiquitination and stabilizes it. Inhibition of CSN5 cooperates with anti-CTLA4 to enhance anti-tumor T cell function and reduce tumor growth.
Author	Lim, Seung-Oe Wu, Yun Yamaguchi, Hirohito Chang, Shih-Shin Ding, Qingqing Hung, Mien-Chie Chan, Li-Chuan Hortobagyi, Gabriel N. Chen, Chung-Hsuan Hsu, Yi-Hsin Wang, Yan Yu, Dihua Hsu, Jung-Mao Sahin, Aysegul A. Hsu, Jennifer L. Li, Chia-Wei Kim, Taewan Xia, Weiya Chang, Wei-Chao Cha, Jong-Ho Lin, Wan-Chi Yang, Yi
AuthorAffiliation	7 Department of Biotechnology, Asia University, Taichung 413, Taiwan 3 Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA 2 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA 5 Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Korea 1 Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA 6 Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University, Taichung 404, Taiwan 4 Graduate School of Biomedical Sciences, The University of Texas Health Science Center, Houston, TX 77030, USA 8 Genomics Research Center, Academia Sinica, Nankang, 115 Taipei, Taiwan
AuthorAffiliation_xml	– name: 2 Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA – name: 5 Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 151-742, Korea – name: 6 Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University, Taichung 404, Taiwan – name: 1 Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – name: 7 Department of Biotechnology, Asia University, Taichung 413, Taiwan – name: 3 Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA – name: 4 Graduate School of Biomedical Sciences, The University of Texas Health Science Center, Houston, TX 77030, USA – name: 8 Genomics Research Center, Academia Sinica, Nankang, 115 Taipei, Taiwan
Author_xml	– sequence: 1 givenname: Seung-Oe surname: Lim fullname: Lim, Seung-Oe organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 2 givenname: Chia-Wei surname: Li fullname: Li, Chia-Wei organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 3 givenname: Weiya surname: Xia fullname: Xia, Weiya organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 4 givenname: Jong-Ho surname: Cha fullname: Cha, Jong-Ho organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 5 givenname: Li-Chuan surname: Chan fullname: Chan, Li-Chuan organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 6 givenname: Yun surname: Wu fullname: Wu, Yun organization: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA – sequence: 7 givenname: Shih-Shin surname: Chang fullname: Chang, Shih-Shin organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 8 givenname: Wan-Chi surname: Lin fullname: Lin, Wan-Chi organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 9 givenname: Jung-Mao surname: Hsu fullname: Hsu, Jung-Mao organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 10 givenname: Yi-Hsin surname: Hsu fullname: Hsu, Yi-Hsin organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 11 givenname: Taewan surname: Kim fullname: Kim, Taewan organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 12 givenname: Wei-Chao surname: Chang fullname: Chang, Wei-Chao organization: Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University, Taichung 404, Taiwan – sequence: 13 givenname: Jennifer L. surname: Hsu fullname: Hsu, Jennifer L. organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 14 givenname: Hirohito surname: Yamaguchi fullname: Yamaguchi, Hirohito organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 15 givenname: Qingqing surname: Ding fullname: Ding, Qingqing organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 16 givenname: Yan surname: Wang fullname: Wang, Yan organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 17 givenname: Yi surname: Yang fullname: Yang, Yi organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 18 givenname: Chung-Hsuan surname: Chen fullname: Chen, Chung-Hsuan organization: Genomics Research Center, Academia Sinica, Nankang, 115 Taipei, Taiwan – sequence: 19 givenname: Aysegul A. surname: Sahin fullname: Sahin, Aysegul A. organization: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA – sequence: 20 givenname: Dihua surname: Yu fullname: Yu, Dihua organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA – sequence: 21 givenname: Gabriel N. surname: Hortobagyi fullname: Hortobagyi, Gabriel N. organization: Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA – sequence: 22 givenname: Mien-Chie surname: Hung fullname: Hung, Mien-Chie email: mhung@mdanderson.org organization: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27866850$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1371/journal.pone.0123410 10.1038/nm730 10.1158/0008-5472.CAN-11-3123 10.1016/j.ccr.2009.03.016 10.1073/pnas.1209345110 10.1016/j.ccr.2011.12.028 10.1038/nature01322 10.1002/j.1460-2075.1992.tb05481.x 10.1126/science.1075901 10.1016/j.ccr.2004.08.012 10.1126/scitranslmed.aad7118 10.1016/j.cell.2007.05.058 10.1084/jem.182.2.459 10.1016/j.ccell.2015.07.004 10.1189/jlb.0610327 10.1038/nrc3239 10.1093/emboj/cdg127 10.2353/ajpath.2009.080861 10.1074/jbc.M406559200 10.1038/embor.2009.64 10.1038/ncomms12632 10.1158/1541-7786.MCR-05-0261 10.1093/emboj/20.7.1630 10.1016/S0092-8674(04)00302-2 10.1038/328267a0 10.4049/jimmunol.170.3.1257 10.1158/1078-0432.CCR-12-2063 10.1200/JCO.2014.59.4358 10.1093/carcin/bgp127 10.1016/1074-7613(94)90071-X 10.1189/jlb.71.1.125 10.1111/j.1600-0625.2008.00740.x 10.1093/embo-reports/kvf024 10.1200/JCO.2009.26.7609 10.1016/0092-8674(92)90030-G 10.1158/0008-5472.CAN-14-3098 10.1371/journal.pone.0061602 10.1038/cr.2010.182
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Copyright	2016 Elsevier Inc. Copyright © 2016 Elsevier Inc. All rights reserved.
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References	Blonska, Lin (bib3) 2011; 21 Echalier, Pan, Birol, Tavernier, Pintard, Hoh, Ebel, Galophe, Claret, Dumas (bib12) 2013; 110 Lu, Ouyang, Huang (bib24) 2006; 4 Aggarwal, Kumar, Bharti (bib1) 2003; 23 Gowrishankar, Gunatilake, Gallagher, Tiffen, Rizos, Hersey (bib15) 2015; 10 Lee, Kuo, Chen, Hsu, Chou, Wei, Sun, Li, Ping, Huang (bib20) 2007; 130 Ishida, Agata, Shibahara, Honjo (bib18) 1992; 11 Colotta, Allavena, Sica, Garlanda, Mantovani (bib8) 2009; 30 Liu, Shah, Xiang, Wang, Deng, Liu, Zhang, Wu, Edmonds, Jambor (bib23) 2009; 174 Cope, Suh, Aravind, Schwarz, Zipursky, Koonin, Deshaies (bib9) 2002; 298 Huang, Wen, Zhao, Gao, Bai (bib17) 2013; 8 Yanagawa, Iijima, Iwabuchi, Onoe (bib38) 2002; 71 Postow, Callahan, Wolchok (bib29) 2015; 33 Fang, Lu, Choi, Yeung, Tung, Hsiao, Fuentes-Mattei, Menter, Chen, Wang (bib13) 2015; 28 Uhle, Medalia, Waldron, Dumdey, Henklein, Bech-Otschir, Huang, Berse, Sperling, Schade, Dubiel (bib33) 2003; 22 Pardoll (bib27) 2012; 12 Dong, Strome, Salomao, Tamura, Hirano, Flies, Roche, Lu, Zhu, Tamada (bib11) 2002; 8 Peng, Hamanishi, Matsumura, Abiko, Murat, Baba, Yamaguchi, Horikawa, Hosoe, Murphy (bib28) 2015; 75 Welteke, Eitelhuber, Duwel, Schweitzer, Naumann, Krappmann (bib37) 2009; 10 Callahan, Postow, Wolchok (bib7) 2014; 4 Wu, Deng, Rychahou, Qiu, Evers, Zhou (bib40) 2009; 15 Brown, Dorfman, Ma, Sullivan, Munoz, Wood, Greenfield, Freeman (bib5) 2003; 170 Wang, Ding, Yen, Xia, Izzo, Lang, Li, Hsu, Miller, Wang (bib36) 2012; 21 Bech-Otschir, Kraft, Huang, Henklein, Kapelari, Pollmann, Dubiel (bib2) 2001; 20 Krummel, Allison (bib19) 1995; 182 Li, Lim, Xia, Lee, Li, Kuo, Khoo, Chang, Cha, Kim (bib22) 2016; 7 Brunet, Denizot, Luciani, Roux-Dosseto, Suzan, Mattei, Golstein (bib6) 1987; 328 Faurschou, Gniadecki (bib14) 2008; 17 Coussens, Werb (bib10) 2002; 420 Wan, Cao, Wu, Bai, Wu, Shi, Wang (bib35) 2002; 3 Rodriguez-Garcia, Porichis, de Jong, Levi, Diefenbach, Lifson, Freeman, Walker, Kaufmann, Kavanagh (bib30) 2011; 89 Sznol, Chen (bib31) 2013; 19 Li, Xia, Huo, Lim, Wu, Hsu, Chao, Yamaguchi, Yang, Ding (bib21) 2012; 72 Brahmer, Drake, Wollner, Powderly, Picus, Sharfman, Stankevich, Pons, Salay, McMiller (bib4) 2010; 28 Tomoda, Yoneda-Kato, Fukumoto, Yamanaka, Kato (bib32) 2004; 279 Luo, Maeda, Hsu, Yagita, Karin (bib25) 2004; 6 Hu, Lee, Xia, Golfman, Ou-Yang, Yang, Zou, Bao, Hanada, Saso (bib16) 2004; 117 Mombaerts, Iacomini, Johnson, Herrup, Tonegawa, Papaioannou (bib26) 1992; 68 Walunas, Lenschow, Bakker, Linsley, Freeman, Green, Thompson, Bluestone (bib34) 1994; 1 Zou, Wolchok, Chen (bib39) 2016; 8 Aggarwal (10.1016/j.ccell.2016.10.010_bib1) 2003; 23 Tomoda (10.1016/j.ccell.2016.10.010_bib32) 2004; 279 Yanagawa (10.1016/j.ccell.2016.10.010_bib38) 2002; 71 Uhle (10.1016/j.ccell.2016.10.010_bib33) 2003; 22 Postow (10.1016/j.ccell.2016.10.010_bib29) 2015; 33 Li (10.1016/j.ccell.2016.10.010_bib21) 2012; 72 Brunet (10.1016/j.ccell.2016.10.010_bib6) 1987; 328 Krummel (10.1016/j.ccell.2016.10.010_bib19) 1995; 182 Callahan (10.1016/j.ccell.2016.10.010_bib7) 2014; 4 Pardoll (10.1016/j.ccell.2016.10.010_bib27) 2012; 12 Wang (10.1016/j.ccell.2016.10.010_bib36) 2012; 21 Liu (10.1016/j.ccell.2016.10.010_bib23) 2009; 174 Dong (10.1016/j.ccell.2016.10.010_bib11) 2002; 8 Rodriguez-Garcia (10.1016/j.ccell.2016.10.010_bib30) 2011; 89 Gowrishankar (10.1016/j.ccell.2016.10.010_bib15) 2015; 10 Sznol (10.1016/j.ccell.2016.10.010_bib31) 2013; 19 Brown (10.1016/j.ccell.2016.10.010_bib5) 2003; 170 Coussens (10.1016/j.ccell.2016.10.010_bib10) 2002; 420 Ishida (10.1016/j.ccell.2016.10.010_bib18) 1992; 11 Mombaerts (10.1016/j.ccell.2016.10.010_bib26) 1992; 68 Peng (10.1016/j.ccell.2016.10.010_bib28) 2015; 75 Colotta (10.1016/j.ccell.2016.10.010_bib8) 2009; 30 Lu (10.1016/j.ccell.2016.10.010_bib24) 2006; 4 Brahmer (10.1016/j.ccell.2016.10.010_bib4) 2010; 28 Echalier (10.1016/j.ccell.2016.10.010_bib12) 2013; 110 Luo (10.1016/j.ccell.2016.10.010_bib25) 2004; 6 Li (10.1016/j.ccell.2016.10.010_bib22) 2016; 7 Bech-Otschir (10.1016/j.ccell.2016.10.010_bib2) 2001; 20 Blonska (10.1016/j.ccell.2016.10.010_bib3) 2011; 21 Wu (10.1016/j.ccell.2016.10.010_bib40) 2009; 15 Zou (10.1016/j.ccell.2016.10.010_bib39) 2016; 8 Lee (10.1016/j.ccell.2016.10.010_bib20) 2007; 130 Walunas (10.1016/j.ccell.2016.10.010_bib34) 1994; 1 Cope (10.1016/j.ccell.2016.10.010_bib9) 2002; 298 Wan (10.1016/j.ccell.2016.10.010_bib35) 2002; 3 Welteke (10.1016/j.ccell.2016.10.010_bib37) 2009; 10 Faurschou (10.1016/j.ccell.2016.10.010_bib14) 2008; 17 Hu (10.1016/j.ccell.2016.10.010_bib16) 2004; 117 Huang (10.1016/j.ccell.2016.10.010_bib17) 2013; 8 Fang (10.1016/j.ccell.2016.10.010_bib13) 2015; 28
References_xml	– volume: 174 start-page: 1415 year: 2009 end-page: 1425 ident: bib23 article-title: COP9-associated CSN5 regulates exosomal protein deubiquitination and sorting publication-title: Am. J. Pathol. – volume: 279 start-page: 43013 year: 2004 end-page: 43018 ident: bib32 article-title: Multiple functions of Jab1 are required for early embryonic development and growth potential in mice publication-title: J. Biol. Chem. – volume: 19 start-page: 1021 year: 2013 end-page: 1034 ident: bib31 article-title: Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer publication-title: Clin. Cancer Res. – volume: 10 start-page: e0123410 year: 2015 ident: bib15 article-title: Inducible but not constitutive expression of PD-L1 in human melanoma cells is dependent on activation of NF-kappaB publication-title: PLoS One – volume: 15 start-page: 416 year: 2009 end-page: 428 ident: bib40 article-title: Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion publication-title: Cancer Cell – volume: 89 start-page: 507 year: 2011 end-page: 515 ident: bib30 article-title: Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10 publication-title: J. Leukoc. Biol. – volume: 23 start-page: 363 year: 2003 end-page: 398 ident: bib1 article-title: Anticancer potential of curcumin: preclinical and clinical studies publication-title: Anticancer Res. – volume: 12 start-page: 252 year: 2012 end-page: 264 ident: bib27 article-title: The blockade of immune checkpoints in cancer immunotherapy publication-title: Nat. Rev. Cancer – volume: 4 start-page: 221 year: 2006 end-page: 233 ident: bib24 article-title: Inflammation, a key event in cancer development publication-title: Mol. Cancer Res. – volume: 7 start-page: 12632 year: 2016 ident: bib22 article-title: Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity publication-title: Nat. Commun. – volume: 33 start-page: 1974 year: 2015 end-page: 1982 ident: bib29 article-title: Immune checkpoint blockade in cancer therapy publication-title: J. Clin. Oncol. – volume: 1 start-page: 405 year: 1994 end-page: 413 ident: bib34 article-title: CTLA-4 can function as a negative regulator of T cell activation publication-title: Immunity – volume: 420 start-page: 860 year: 2002 end-page: 867 ident: bib10 article-title: Inflammation and cancer publication-title: Nature – volume: 328 start-page: 267 year: 1987 end-page: 270 ident: bib6 article-title: A new member of the immunoglobulin superfamily–CTLA-4 publication-title: Nature – volume: 8 start-page: e61602 year: 2013 ident: bib17 article-title: NF-kappaB plays a key role in inducing CD274 expression in human monocytes after lipopolysaccharide treatment publication-title: PLoS One – volume: 71 start-page: 125 year: 2002 end-page: 132 ident: bib38 article-title: Activation of extracellular signal-related kinase by TNF-alpha controls the maturation and function of murine dendritic cells publication-title: J. Leukoc. Biol. – volume: 10 start-page: 642 year: 2009 end-page: 648 ident: bib37 article-title: COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation publication-title: EMBO Rep. – volume: 22 start-page: 1302 year: 2003 end-page: 1312 ident: bib33 article-title: Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome publication-title: EMBO J. – volume: 4 start-page: 385 year: 2014 ident: bib7 article-title: CTLA-4 and PD-1 pathway blockade: combinations in the clinic publication-title: Front Oncol. – volume: 117 start-page: 225 year: 2004 end-page: 237 ident: bib16 article-title: IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a publication-title: Cell – volume: 28 start-page: 183 year: 2015 end-page: 197 ident: bib13 article-title: ERK2-Dependent phosphorylation of CSN6 is critical in colorectal cancer development publication-title: Cancer Cell – volume: 20 start-page: 1630 year: 2001 end-page: 1639 ident: bib2 article-title: COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system publication-title: EMBO J. – volume: 298 start-page: 608 year: 2002 end-page: 611 ident: bib9 article-title: Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1 publication-title: Science – volume: 6 start-page: 297 year: 2004 end-page: 305 ident: bib25 article-title: Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression publication-title: Cancer Cell – volume: 75 start-page: 5034 year: 2015 end-page: 5045 ident: bib28 article-title: Chemotherapy induces programmed cell death-ligand 1 overexpression via the nuclear factor-kappaB to foster an immunosuppressive tumor microenvironment in ovarian cancer publication-title: Cancer Res. – volume: 182 start-page: 459 year: 1995 end-page: 465 ident: bib19 article-title: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation publication-title: J. Exp. Med. – volume: 170 start-page: 1257 year: 2003 end-page: 1266 ident: bib5 article-title: Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production publication-title: J. Immunol. – volume: 72 start-page: 1290 year: 2012 end-page: 1300 ident: bib21 article-title: Epithelial-mesenchymal transition induced by TNF-alpha requires NF-kappaB-mediated transcriptional upregulation of Twist1 publication-title: Cancer Res. – volume: 8 start-page: 793 year: 2002 end-page: 800 ident: bib11 article-title: Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion publication-title: Nat. Med. – volume: 130 start-page: 440 year: 2007 end-page: 455 ident: bib20 article-title: IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway publication-title: Cell – volume: 21 start-page: 55 year: 2011 end-page: 70 ident: bib3 article-title: NF-kappaB signaling pathways regulated by CARMA family of scaffold proteins publication-title: Cell Res. – volume: 68 start-page: 869 year: 1992 end-page: 877 ident: bib26 article-title: RAG-1-deficient mice have no mature B and T lymphocytes publication-title: Cell – volume: 28 start-page: 3167 year: 2010 end-page: 3175 ident: bib4 article-title: Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates publication-title: J. Clin. Oncol. – volume: 8 start-page: 328rv324 year: 2016 ident: bib39 article-title: PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: mechanisms, response biomarkers, and combinations publication-title: Sci. Transl. Med. – volume: 30 start-page: 1073 year: 2009 end-page: 1081 ident: bib8 article-title: Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability publication-title: Carcinogenesis – volume: 17 start-page: 992 year: 2008 end-page: 997 ident: bib14 article-title: TNF-alpha stimulates Akt by a distinct aPKC-dependent pathway in premalignant keratinocytes publication-title: Exp. Dermatol. – volume: 21 start-page: 374 year: 2012 end-page: 387 ident: bib36 article-title: The crosstalk of mTOR/S6K1 and Hedgehog pathways publication-title: Cancer Cell – volume: 110 start-page: 1273 year: 2013 end-page: 1278 ident: bib12 article-title: Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1 publication-title: Proc. Natl. Acad. Sci. USA – volume: 3 start-page: 171 year: 2002 end-page: 176 ident: bib35 article-title: Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation publication-title: EMBO Rep. – volume: 11 start-page: 3887 year: 1992 end-page: 3895 ident: bib18 article-title: Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death publication-title: EMBO J. – volume: 10 start-page: e0123410 year: 2015 ident: 10.1016/j.ccell.2016.10.010_bib15 article-title: Inducible but not constitutive expression of PD-L1 in human melanoma cells is dependent on activation of NF-kappaB publication-title: PLoS One doi: 10.1371/journal.pone.0123410 – volume: 8 start-page: 793 year: 2002 ident: 10.1016/j.ccell.2016.10.010_bib11 article-title: Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion publication-title: Nat. Med. doi: 10.1038/nm730 – volume: 72 start-page: 1290 year: 2012 ident: 10.1016/j.ccell.2016.10.010_bib21 article-title: Epithelial-mesenchymal transition induced by TNF-alpha requires NF-kappaB-mediated transcriptional upregulation of Twist1 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-11-3123 – volume: 15 start-page: 416 year: 2009 ident: 10.1016/j.ccell.2016.10.010_bib40 article-title: Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion publication-title: Cancer Cell doi: 10.1016/j.ccr.2009.03.016 – volume: 110 start-page: 1273 year: 2013 ident: 10.1016/j.ccell.2016.10.010_bib12 article-title: Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1209345110 – volume: 21 start-page: 374 year: 2012 ident: 10.1016/j.ccell.2016.10.010_bib36 article-title: The crosstalk of mTOR/S6K1 and Hedgehog pathways publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.12.028 – volume: 420 start-page: 860 year: 2002 ident: 10.1016/j.ccell.2016.10.010_bib10 article-title: Inflammation and cancer publication-title: Nature doi: 10.1038/nature01322 – volume: 11 start-page: 3887 year: 1992 ident: 10.1016/j.ccell.2016.10.010_bib18 article-title: Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death publication-title: EMBO J. doi: 10.1002/j.1460-2075.1992.tb05481.x – volume: 298 start-page: 608 year: 2002 ident: 10.1016/j.ccell.2016.10.010_bib9 article-title: Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1 publication-title: Science doi: 10.1126/science.1075901 – volume: 6 start-page: 297 year: 2004 ident: 10.1016/j.ccell.2016.10.010_bib25 article-title: Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression publication-title: Cancer Cell doi: 10.1016/j.ccr.2004.08.012 – volume: 8 start-page: 328rv324 year: 2016 ident: 10.1016/j.ccell.2016.10.010_bib39 article-title: PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: mechanisms, response biomarkers, and combinations publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aad7118 – volume: 130 start-page: 440 year: 2007 ident: 10.1016/j.ccell.2016.10.010_bib20 article-title: IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway publication-title: Cell doi: 10.1016/j.cell.2007.05.058 – volume: 182 start-page: 459 year: 1995 ident: 10.1016/j.ccell.2016.10.010_bib19 article-title: CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation publication-title: J. Exp. Med. doi: 10.1084/jem.182.2.459 – volume: 28 start-page: 183 year: 2015 ident: 10.1016/j.ccell.2016.10.010_bib13 article-title: ERK2-Dependent phosphorylation of CSN6 is critical in colorectal cancer development publication-title: Cancer Cell doi: 10.1016/j.ccell.2015.07.004 – volume: 89 start-page: 507 year: 2011 ident: 10.1016/j.ccell.2016.10.010_bib30 article-title: Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10 publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.0610327 – volume: 12 start-page: 252 year: 2012 ident: 10.1016/j.ccell.2016.10.010_bib27 article-title: The blockade of immune checkpoints in cancer immunotherapy publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3239 – volume: 22 start-page: 1302 year: 2003 ident: 10.1016/j.ccell.2016.10.010_bib33 article-title: Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome publication-title: EMBO J. doi: 10.1093/emboj/cdg127 – volume: 174 start-page: 1415 year: 2009 ident: 10.1016/j.ccell.2016.10.010_bib23 article-title: COP9-associated CSN5 regulates exosomal protein deubiquitination and sorting publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2009.080861 – volume: 279 start-page: 43013 year: 2004 ident: 10.1016/j.ccell.2016.10.010_bib32 article-title: Multiple functions of Jab1 are required for early embryonic development and growth potential in mice publication-title: J. Biol. Chem. doi: 10.1074/jbc.M406559200 – volume: 10 start-page: 642 year: 2009 ident: 10.1016/j.ccell.2016.10.010_bib37 article-title: COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation publication-title: EMBO Rep. doi: 10.1038/embor.2009.64 – volume: 23 start-page: 363 year: 2003 ident: 10.1016/j.ccell.2016.10.010_bib1 article-title: Anticancer potential of curcumin: preclinical and clinical studies publication-title: Anticancer Res. – volume: 7 start-page: 12632 year: 2016 ident: 10.1016/j.ccell.2016.10.010_bib22 article-title: Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity publication-title: Nat. Commun. doi: 10.1038/ncomms12632 – volume: 4 start-page: 221 year: 2006 ident: 10.1016/j.ccell.2016.10.010_bib24 article-title: Inflammation, a key event in cancer development publication-title: Mol. Cancer Res. doi: 10.1158/1541-7786.MCR-05-0261 – volume: 20 start-page: 1630 year: 2001 ident: 10.1016/j.ccell.2016.10.010_bib2 article-title: COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system publication-title: EMBO J. doi: 10.1093/emboj/20.7.1630 – volume: 117 start-page: 225 year: 2004 ident: 10.1016/j.ccell.2016.10.010_bib16 article-title: IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a publication-title: Cell doi: 10.1016/S0092-8674(04)00302-2 – volume: 328 start-page: 267 year: 1987 ident: 10.1016/j.ccell.2016.10.010_bib6 article-title: A new member of the immunoglobulin superfamily–CTLA-4 publication-title: Nature doi: 10.1038/328267a0 – volume: 170 start-page: 1257 year: 2003 ident: 10.1016/j.ccell.2016.10.010_bib5 article-title: Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production publication-title: J. Immunol. doi: 10.4049/jimmunol.170.3.1257 – volume: 19 start-page: 1021 year: 2013 ident: 10.1016/j.ccell.2016.10.010_bib31 article-title: Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-12-2063 – volume: 33 start-page: 1974 year: 2015 ident: 10.1016/j.ccell.2016.10.010_bib29 article-title: Immune checkpoint blockade in cancer therapy publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2014.59.4358 – volume: 4 start-page: 385 year: 2014 ident: 10.1016/j.ccell.2016.10.010_bib7 article-title: CTLA-4 and PD-1 pathway blockade: combinations in the clinic publication-title: Front Oncol. – volume: 30 start-page: 1073 year: 2009 ident: 10.1016/j.ccell.2016.10.010_bib8 article-title: Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability publication-title: Carcinogenesis doi: 10.1093/carcin/bgp127 – volume: 1 start-page: 405 year: 1994 ident: 10.1016/j.ccell.2016.10.010_bib34 article-title: CTLA-4 can function as a negative regulator of T cell activation publication-title: Immunity doi: 10.1016/1074-7613(94)90071-X – volume: 71 start-page: 125 year: 2002 ident: 10.1016/j.ccell.2016.10.010_bib38 article-title: Activation of extracellular signal-related kinase by TNF-alpha controls the maturation and function of murine dendritic cells publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.71.1.125 – volume: 17 start-page: 992 year: 2008 ident: 10.1016/j.ccell.2016.10.010_bib14 article-title: TNF-alpha stimulates Akt by a distinct aPKC-dependent pathway in premalignant keratinocytes publication-title: Exp. Dermatol. doi: 10.1111/j.1600-0625.2008.00740.x – volume: 3 start-page: 171 year: 2002 ident: 10.1016/j.ccell.2016.10.010_bib35 article-title: Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation publication-title: EMBO Rep. doi: 10.1093/embo-reports/kvf024 – volume: 28 start-page: 3167 year: 2010 ident: 10.1016/j.ccell.2016.10.010_bib4 article-title: Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2009.26.7609 – volume: 68 start-page: 869 year: 1992 ident: 10.1016/j.ccell.2016.10.010_bib26 article-title: RAG-1-deficient mice have no mature B and T lymphocytes publication-title: Cell doi: 10.1016/0092-8674(92)90030-G – volume: 75 start-page: 5034 year: 2015 ident: 10.1016/j.ccell.2016.10.010_bib28 article-title: Chemotherapy induces programmed cell death-ligand 1 overexpression via the nuclear factor-kappaB to foster an immunosuppressive tumor microenvironment in ovarian cancer publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-3098 – volume: 8 start-page: e61602 year: 2013 ident: 10.1016/j.ccell.2016.10.010_bib17 article-title: NF-kappaB plays a key role in inducing CD274 expression in human monocytes after lipopolysaccharide treatment publication-title: PLoS One doi: 10.1371/journal.pone.0061602 – volume: 21 start-page: 55 year: 2011 ident: 10.1016/j.ccell.2016.10.010_bib3 article-title: NF-kappaB signaling pathways regulated by CARMA family of scaffold proteins publication-title: Cell Res. doi: 10.1038/cr.2010.182
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Snippet	Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current...
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SubjectTerms	Animals anti-CTLA4 B7-H1 Antigen - chemistry B7-H1 Antigen - metabolism Cell Line, Tumor COP9 Signalosome Complex CSN5 curcumin Curcumin - pharmacology deubiquitination Female Humans Intracellular Signaling Peptides and Proteins - metabolism Mice Neoplasm Transplantation Neoplasms - metabolism NF-kappa B - metabolism PD-L1 Peptide Hydrolases - metabolism Protein Stability TNF-α Tumor Necrosis Factor-alpha - metabolism Ubiquitination
Title	Deubiquitination and Stabilization of PD-L1 by CSN5
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