Research Resource: Haploinsufficiency of Receptor Activity-Modifying Protein-2 (Ramp2) Causes Reduced Fertility, Hyperprolactinemia, Skeletal Abnormalities, and Endocrine Dysfunction in Mice

• Published in: Molecular endocrinology (Baltimore, Md.) Vol. 25; no. 7; pp. 1244 - 1253
• Main Authors: Kadmiel, Mahita, Fritz-Six, Kimberly, Pacharne, Suruchi, Richards, Gareth O, Li, Manyu, Skerry, Tim M, Caron, Kathleen M
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.07.2011; Oxford University Press
• Subjects: Animals; Animals, Newborn; Bone and Bones - abnormalities; Bone and Bones - diagnostic imaging; Bone Density; Bone Development; Female; Femur - abnormalities; Femur - diagnostic imaging; Fetal Death - genetics; Genes, Lethal; Haploinsufficiency; Hyperplasia; Hyperprolactinemia - genetics; Infertility, Female - genetics; Lumbar Vertebrae - abnormalities; Lumbar Vertebrae - diagnostic imaging; Male; Mammary Glands, Animal - abnormalities; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Pituitary Gland - pathology; Pregnancy; Radiography; Receptor Activity-Modifying Protein 2 - genetics; Research Resource; Tibia - abnormalities; Tibia - diagnostic imaging

Receptor activity-modifying protein-2 (RAMP2) is a single-pass transmembrane protein that can regulate the trafficking, ligand binding, and signaling of several G protein-coupled receptors (GPCR). The most well-characterized role of RAMP2 is in the regulation of adrenomedullin (AM) binding to calcit...