Assessment of β-amyloid deposits in human brain: a study of the BrainNet Europe Consortium

• Published in: Acta neuropathologica Vol. 117; no. 3; pp. 309 - 320
• Main Authors: Alafuzoff, Irina, Thal, Dietmar R., Arzberger, Thomas, Bogdanovic, Nenad, Al-Sarraj, Safa, Bodi, Istvan, Boluda, Susan, Bugiani, Orso, Duyckaerts, Charles, Gelpi, Ellen, Gentleman, Stephen, Giaccone, Giorgio, Graeber, Manuel, Hortobagyi, Tibor, Höftberger, Romana, Ince, Paul, Ironside, James W., Kavantzas, Nikolaos, King, Andrew, Korkolopoulou, Penelope, Kovács, Gábor G., Meyronet, David, Monoranu, Camelia, Nilsson, Tatjana, Parchi, Piero, Patsouris, Efstratios, Pikkarainen, Maria, Revesz, Tamas, Rozemuller, Annemieke, Seilhean, Danielle, Schulz-Schaeffer, Walter, Streichenberger, Nathalie, Wharton, Stephen B., Kretzschmar, Hans
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.03.2009
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Amyloid beta-Peptides - biosynthesis; Amyloid beta-Peptides - metabolism; Brain - metabolism; Brain - pathology; Cerebral Amyloid Angiopathy - metabolism; Cerebral Amyloid Angiopathy - pathology; Cerebral Amyloid Angiopathy - physiopathology; Cerebral Arteries - metabolism; Cerebral Arteries - pathology; Cerebral Arteries - physiopathology; Dermatologi och venerologi, klinisk genetik, invärtesmedicin; Dermatology and venerology,clinical genetics, internal medicine; Disease Progression; Female; Humans; Immunohistochemistry; Internal medicine; Invärtesmedicin; Male; MEDICIN; Medicin och hälsovetenskap; MEDICINE; Medicine & Public Health; Middle Aged; Morfologi, cellbiologi, patologi; Morphology, cell biology, pathology; Neurologi; Neurology; Neurosciences; Original Paper; Pathology; Patologi; Reference Values; Reproducibility of Results; Absolute Agreement; Cerebral Amyloid Angiopathy; Occipital Cortex; Agreement Rate; Tauopathy

β-Amyloid (Aβ) related pathology shows a range of lesions which differ both qualitatively and quantitatively. Pathologists, to date, mainly focused on the assessment of both of these aspects but attempts to correlate the findings with clinical phenotypes are not convincing. It has been recently prop...