Gut microbiota-derived short chain fatty acids are potential mediators in gut inflammation

• Published in: Animal Nutrition Vol. 8; pp. 350 - 360
• Main Authors: Akhtar, Muhammad, Chen, Yan, Ma, Ziyu, Zhang, Xiaolong, Shi, Deshi, Khan, Jawaria A., Liu, Huazhen
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.03.2022; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: animal nutrition; antibiotics; digestive system; fermentation; Gut homeostasis; Gut inflammation; Gut microbiota; homeostasis; inflammation; Inflammatory bowel disease; intestinal microorganisms; metabolites; Review; Short chain fatty acid; therapeutics; Gut microbiota; Inflammatory bowel disease; Short chain fatty acid; Gut homeostasis; Gut inflammation
• ISSN: 2405-6545; 2405-6383; 2405-6383
• DOI: 10.1016/j.aninu.2021.11.005

Gut inflammation is a challenging concern in humans and animals, which disturbs normal growth and leads to severe bowel diseases. Short chain fatty acids (SCFA) are the gut microbiota metabolites produced from fermentation of non-digestible carbohydrates, and have been reported to modulate gut inflammation. SCFA have been implicated as the potential therapeutic bioactive molecules for gut inflammatory diseases, and could be an alternative to antibiotic growth promoters (AGP). In this review, the existing knowledge about the types of SCFA, the related gut microbes producing SCFA, the roles of SCFA in maintaining gut homeostasis, and how SCFA modulate gut inflammation is summarized. The therapeutic application of SCFA in the treatment of inflammatory bowel disease (IBD) is also highlighted. [Display omitted]