Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins

• Published in: Biological psychiatry (1969) Vol. 52; no. 7; pp. 708 - 715
• Main Authors: Beasley, Clare L, Zhang, Zhi J, Patten, Iain, Reynolds, Gavin P
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2002; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; bipolar disorder; calbindin; Calbindin 2; Calbindins; Calcium-Binding Proteins - metabolism; calretinin; Cell Count; Female; gamma-Aminobutyric Acid - metabolism; Humans; Immunohistochemistry; interneuron; Interneurons - metabolism; Interneurons - pathology; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Nervous system; Parvalbumin; Parvalbumins - metabolism; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Prefrontal Cortex - metabolism; Prefrontal Cortex - pathology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; S100 Calcium Binding Protein G - metabolism; Schizophrenia; Schizophrenia - metabolism; Schizophrenia - pathology; calbindin; interneuron; bipolar disorder; calretinin; schizophrenia; Parvalbumin; Mood disorder; Human; Calbindin; Calcium; Calretinin; Immunocytochemistry; Pathogenesis; Postmortem; Schizophrenia; Bipolar disorder; Prefrontal cortex; Interneuron; Gabaergic pathway; Psychosis; Case study; Pathology; Binding protein; Mental disorder

Background: Postmortem studies have provided evidence for abnormalities of the γ-aminobutyric acid (GABA)-ergic system in schizophrenia, including deficits of GABA-containing interneurons. The calcium-binding proteins parvalbumin, calbindin, and calretinin can be used as markers for specific subpopu...