p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

• Published in: Cancer cell Vol. 29; no. 6; pp. 935 - 948
• Main Authors: Umemura, Atsushi, He, Feng, Taniguchi, Koji, Nakagawa, Hayato, Yamachika, Shinichiro, Font-Burgada, Joan, Zhong, Zhenyu, Subramaniam, Shankar, Raghunandan, Sindhu, Duran, Angeles, Linares, Juan F., Reina-Campos, Miguel, Umemura, Shiori, Valasek, Mark A., Seki, Ekihiro, Yamaguchi, Kanji, Koike, Kazuhiko, Itoh, Yoshito, Diaz-Meco, Maria T., Moscat, Jorge, Karin, Michael
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.06.2016
• Subjects: Animals; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Cell Survival; Diethylnitrosamine - adverse effects; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Transgenic; Multiprotein Complexes - genetics; Neoplasms, Experimental; Neoplastic Stem Cells - cytology; Neoplastic Stem Cells - drug effects; NF-E2-Related Factor 2 - genetics; Proto-Oncogene Proteins c-myc - genetics; Sequestosome-1 Protein - genetics; TOR Serine-Threonine Kinases - genetics; Up-Regulation

p62 is a ubiquitin-binding autophagy receptor and signaling protein that accumulates in premalignant liver diseases and most hepatocellular carcinomas (HCCs). Although p62 was proposed to participate in the formation of benign adenomas in autophagy-deficient livers, its role in HCC initiation was no...