Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats

• Published in: Blood Vol. 118; no. 18; pp. 4977 - 4984
• Main Authors: Theurl, Igor, Schroll, Andrea, Sonnweber, Thomas, Nairz, Manfred, Theurl, Milan, Willenbacher, Wolfgang, Eller, Kathrin, Wolf, Dominik, Seifert, Markus, Sun, Chia Chi, Babitt, Jodie L., Hong, Charles C., Menhall, Tracey, Gearing, Patrick, Lin, Herbert Y., Weiss, Guenter
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 03.11.2011; Americain Society of Hematology; American Society of Hematology
• Subjects: Anemia - drug therapy; Anemia - etiology; Anemia - genetics; Anemias. Hemoglobinopathies; Animals; Antimicrobial Cationic Peptides - antagonists & inhibitors; Antimicrobial Cationic Peptides - genetics; Antimicrobial Cationic Peptides - metabolism; Biological and medical sciences; Cells, Cultured; Chronic Disease; Disease Models, Animal; Diseases of red blood cells; Drug Evaluation, Preclinical; Female; Gene Expression - drug effects; GPI-Linked Proteins; Hematologic and hematopoietic diseases; Hemochromatosis Protein; Hepcidins; Immunoglobulin Fc Fragments - therapeutic use; Inflammation - complications; Inflammation - drug therapy; Inflammation - genetics; Medical sciences; Membrane Proteins - immunology; Pyrazoles - pharmacology; Pyrimidines - pharmacology; Rats; Rats, Inbred Lew; Red Cells, Iron, and Erythropoiesis; Remission Induction; Hematology; Rat; Anemia; Rodentia; Hemopathy; Inflammation; Vertebrata; Chronic; Mammalia; Animal; Reversibility; Inhibitor; Hepcidin

Anemia of chronic inflammation (ACI) is the most frequent anemia in hospitalized patients and is associated with significant morbidity. A major underlying mechanism of ACI is the retention of iron within cells of the reticuloendothelial system (RES), thus making the metal unavailable for efficient e...