Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci

• Published in: Kidney international Vol. 88; no. 4; pp. 823 - 832
• Main Authors: Stafford-Smith, Mark, Li, Yi-Ju, Mathew, Joseph P., Li, Yen-Wei, Ji, Yunqi, Phillips-Bute, Barbara G., Milano, Carmelo A., Newman, Mark F., Kraus, William E., Kertai, Miklos D., Shah, Svati H., Podgoreanu, Mihai V.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2015; Elsevier Limited
• Subjects: acute kidney injury; Acute Kidney Injury - blood; Acute Kidney Injury - diagnosis; Acute Kidney Injury - genetics; Aged; BBS9; Biomarkers - blood; Coronary Artery Bypass - adverse effects; coronary artery bypass graft surgery; Creatinine - blood; Databases, Genetic; Female; Genetic Loci; Genetic Markers; Genetic Predisposition to Disease; Genome-Wide Association Study; GWAS; Humans; Linear Models; Male; Middle Aged; Pegasus; Phenotype; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Time Factors; coronary artery bypass graft surgery; BBS9; acute kidney injury; GWAS

Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide association study (GWAS) for AKI following coronary bypass graft (CABG) surgery. The discovery data set consisted of 87...