Angiotensin II receptors and drug discovery in cardiovascular disease

• Published in: Drug discovery today Vol. 16; no. 1; pp. 22 - 34
• Main Authors: Dasgupta, Chiranjib, Zhang, Lubo
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.01.2011; Elsevier
• Subjects: Angiotensin II - metabolism; Angiotensin Receptor Antagonists - chemistry; Angiotensin Receptor Antagonists - pharmacology; Animals; Biological and medical sciences; Cardiovascular Agents - pharmacology; Cardiovascular Diseases - drug therapy; Cardiovascular Diseases - genetics; Cardiovascular Diseases - metabolism; Drug Discovery - methods; Female; General pharmacology; Humans; Medical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Pregnancy; Receptors, Angiotensin - biosynthesis; Receptors, Angiotensin - genetics; Receptors, Angiotensin - metabolism; Drug; Cardiovascular disease; Angiotensin II receptor; Pharmaceutical technology; Research and development

Hypertension is one of the cardiovascular diseases that might cause cardiovascular remodeling and endothelial dysfunction besides high blood pressure. Angiotensin II (Ang II) receptors are implicated in hypertension. Genetic and epigenetic manipulations of the Ang II receptors play a crucial part in...