Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

• Published in: Blood Vol. 119; no. 3; pp. 756 - 766
• Main Authors: Montecalvo, Angela, Larregina, Adriana T., Shufesky, William J., Beer Stolz, Donna, Sullivan, Mara L.G., Karlsson, Jenny M., Baty, Catherine J., Gibson, Gregory A., Erdos, Geza, Wang, Zhiliang, Milosevic, Jadranka, Tkacheva, Olga A., Divito, Sherrie J., Jordan, Rick, Lyons-Weiler, James, Watkins, Simon C., Morelli, Adrian E.
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 19.01.2012; Americain Society of Hematology; American Society of Hematology
• Subjects: Animals; Antigen Presentation; Biological and medical sciences; Biomarkers - metabolism; Cell Communication; Cytosol - metabolism; Dendritic Cells - cytology; Dendritic Cells - metabolism; Endosomes - metabolism; Exosomes - genetics; Exosomes - metabolism; Gene Expression Profiling; Hematologic and hematopoietic diseases; Immunobiology; Medical sciences; Membrane Fusion; Mice; MicroRNAs - physiology; Oligonucleotide Array Sequence Analysis; Dendritic cell; RNA interference; Hematology; Rodentia; Micro RNA; Mechanism; Gene silencing; Vertebrata; Mammalia; Mouse; Antigen presenting cell; Exosome; Animal

Dendritic cells (DCs) are the most potent APCs. Whereas immature DCs down-regulate T-cell responses to induce/maintain immunologic tolerance, mature DCs promote immunity. To amplify their functions, DCs communicate with neighboring DCs through soluble mediators, cell-to-cell contact, and vesicle exc...