3-O-Acyl-epicatechins Increase Glucose Uptake Activity and GLUT4 Translocation through Activation of PI3K Signaling in Skeletal Muscle Cells

• Published in: International journal of molecular sciences Vol. 16; no. 7; pp. 16288 - 16299
• Main Authors: Ueda-Wakagi, Manabu, Mukai, Rie, Fuse, Naoya, Mizushina, Yoshiyuki, Ashida, Hitoshi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.07.2015; MDPI
• Subjects: Animals; Catechin - chemistry; Catechin - pharmacology; Cellular biology; Glucose; Glucose - metabolism; Glucose Transporter Type 4 - metabolism; Insulin; Insulin - pharmacology; Lipid Bilayers - metabolism; Muscle Cells - drug effects; Muscle Cells - metabolism; Muscle Fibers, Skeletal - drug effects; Muscle Fibers, Skeletal - metabolism; Muscle, Skeletal - cytology; Phosphatidylinositol 3-Kinases - metabolism; Polyphenols; Protein Transport - drug effects; Rats; Signal Transduction - drug effects; Tea; glucose transporter 4; skeletal muscle; insulin signaling pathway; acyl catechin

Tea catechins promote glucose uptake in skeletal muscle cells. In this study, we investigated whether the addition of an acyl group to the C-3 position of catechins to generate 3-O-acyl-catechins promoted glucose uptake in L6 myotubes. 3-O-Myristoyl-(−)-epicatechin (EC-C14) and 3-O-palmitoyl-(−)-epi...