Rational Design and Characterization of Trispecific Antibodies Targeting the HIV-1 Receptor and Envelope Glycoprotein

• Published in: Vaccines (Basel) Vol. 12; no. 1; p. 19
• Main Authors: Liang, Jinhu, Zhai, Linlin, Liang, Zuxin, Chen, Xiaoling, Jiang, Yushan, Lin, Yuanlong, Feng, Shiyan, Liu, Yingxia, Zhao, Wei, Wang, Fuxiang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.12.2023; MDPI
• Subjects: Anti-HIV agents; Antibodies; Antigens; Antiviral agents; Binding sites; CC chemokine receptors; CCR5; CD4 antigen; Chromatography; Cloning; Cytomegalovirus; Dialysate; Drugs; Enzyme-linked immunosorbent assay; Glycoproteins; HIV; HIV (Viruses); HIV antibodies; HIV-1; host receptor CD4; Human immunodeficiency virus; Infections; Laboratory animals; Medical research; Medicine, Experimental; Neutralization; neutralizing antibodies; Pharmacology; Physiological aspects; Plasmids; Product development; Proteins; Receptor antibodies; Receptors; trispecific antibodies; Viral infections; Viruses; China; Beijing China; Chicago Illinois; United States > US; HIV-1; trispecific antibodies; neutralizing antibodies; host receptor CD4; CCR5

Multitudinous broadly neutralizing antibodies (bNAbs) against HIV-1 have been developed as novel antiviral prophylactic and therapeutic agents. Combinations of bNAbs are generally even more effective than when they are applied individually, showing excellent neutralization coverage and limiting the...