Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles

• Published in: Biomaterials Vol. 32; no. 32; pp. 8281 - 8290
• Main Authors: Wang, Hai, Zhao, Ying, Wu, Yan, Hu, Yu-lin, Nan, Kaihui, Nie, Guangjun, Chen, Hao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.11.2011
• Subjects: Advanced Basic Science; Animals; anticarcinogenic activity; Antineoplastic Agents - pharmacology; Antitumor agents; Cell Death - drug effects; cell growth; Cell Line, Tumor; Cell Survival - drug effects; Chromatography, High Pressure Liquid; Co-delivery of drugs; composite polymers; Controlled drug release; Dentistry; Double emulsion; doxorubicin; Doxorubicin - pharmacology; Drug Delivery Systems; drug resistance; Drug Stability; Drug Synergism; drug therapy; emulsions; ethylene glycol; Fluorescein-5-isothiocyanate; Humans; hydrophilicity; hydrophobicity; Intracellular Space - drug effects; Intracellular Space - metabolism; Light; Mice; micelles; Multifunctional nanoparticles; nanocarriers; nanoparticles; Nanoparticles - chemistry; Nanoparticles - ultrastructure; Nanotechnology; neoplasm cells; paclitaxel; Paclitaxel - pharmacology; Particle Size; Polyesters - chemistry; Polyethylene Glycols - chemistry; Scattering, Radiation; Surface-Active Agents - chemistry; synergism; toxicity; EE; Co-delivery of drugs; Double emulsion; mPEG-PLGA; TAX; DLS; DOX; NPs; FITC; NMR; Controlled drug release; FTIR; Multifunctional nanoparticles; PVA; TEM; Nanotechnology; HPLC; W/O/W; fourier-transform infrared spectroscopy; water-in-oil-in-water; nanoparticles; High pressure liquid chromatography; doxorubicin; transmission electron microscopy; fluorescein isothiocyanate; paclitaxel; dynamic light scattering; encapsulation efficiency; methoxy poly(ethylene glycol)-poly(lactide-co-glycolide); nuclear magnetic resonance; polyvinyl alcohol

The use of single chemotherapeutic drug has shown some limitations in anti-tumor treatment, such as development of drug resistance, high toxicity and limited regime of clinical uses. The combination of two or more therapeutic drugs is feasible means to overcome the limitations. Co-delivery strategy...