Ironing Out Cancer

New insights into the roles of proteins that regulate cellular iron in cancer growth, angiogenesis, and metastasis have recently emerged. Discoveries of the roles of ferroportin, hepcidin, lipocalin 2, and members of the six transmembrane epithelial antigen of the prostate (STEAP) and iron regulator...

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Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 71; no. 5; pp. 1511 - 1514
Main Authors TORTI, Suzy V, TORTI, Frank M
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 01.03.2011
Subjects
Animals
Antineoplastic agents
Biological and medical sciences
Disease Progression
Homeostasis
Humans
Iron - metabolism
Medical sciences
Neoplasms - metabolism
Neoplasms - pathology
Pharmacology. Drug treatments
Tumors
Malignant tumor
Cancer
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Summary:New insights into the roles of proteins that regulate cellular iron in cancer growth, angiogenesis, and metastasis have recently emerged. Discoveries of the roles of ferroportin, hepcidin, lipocalin 2, and members of the six transmembrane epithelial antigen of the prostate (STEAP) and iron regulatory protein (IRP) families in cancer have provided specificity and molecular definition to the role of iron homeostasis in cancer growth and metastasis. A number of studies directly support a role of these proteins in modifying bioavailable iron, whereas other studies suggest that at least some of their effects are independent of their role in iron biology.
Bibliography:ObjectType-Article-2
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ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.can-10-3614