MTA1 Coregulator Regulates p53 Stability and Function

• Published in: The Journal of biological chemistry Vol. 284; no. 50; pp. 34545 - 34552
• Main Authors: Li, Da-Qiang, Divijendra Natha Reddy, Sirigiri, Pakala, Suresh B., Wu, Xifeng, Zhang, Yanping, Rayala, Suresh K., Kumar, Rakesh
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.12.2009; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Cell Line, Tumor; Cells, Cultured; DNA Damage; DNA Repair; Fibroblasts - cytology; Fibroblasts - physiology; Humans; Mechanisms of Signal Transduction; Mice; Mice, Knockout; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Proto-Oncogene Proteins c-mdm2 - genetics; Proto-Oncogene Proteins c-mdm2 - metabolism; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - metabolism; Repressor Proteins; Trans-Activators; Transcription Factors - genetics; Transcription Factors - metabolism; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism

Although metastasis-associated protein 1 (MTA1) has recently been shown as a DNA damage responsive protein, the underlying mechanism for its role in DNA double-strand break (DSB) repair remains unknown. Here, we show that MTA1 controls p53 stability through inhibiting its ubiquitination by E3 ubiqui...