Post-operative cardiac arrest induced by co-administration of amiodarone and dexmedetomidine: a case report

We firstly report a postoperative hemodialysis patient who was co-administered with amiodarone and dexmedetomidine and developed severe bradycardia followed by cardiac arrest. A 79-year-old male patient underwent an amputation of the right lower extremity. The electrocardiogram of the patient showed...

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Published inJournal of intensive care Vol. 3; no. 1; p. 43
Main Authors Ohmori, Takafumi, Shiota, Nobuhiro, Haramo, Akihiro, Masuda, Takahiro, Maruyama, Fumi, Wakabayashi, Kenji, Adachi, Yushi U, Nakazawa, Koichi
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 21.10.2015
BioMed Central
Subjects
Analysis
Cardiac arrest
Cardiac arrhythmia
Case Report
College professors
Complications and side effects
Consent
Drug dosages
Electrocardiogram
Electrocardiography
Health aspects
Heart attacks
Heart beat
Heart rate
Hemodialysis
Intensive care
Laboratories
Medicine
Sinuses
Surgery
Tachycardia
Amiodarone
Cardiac arrest
Dexmedetomidine
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Summary:We firstly report a postoperative hemodialysis patient who was co-administered with amiodarone and dexmedetomidine and developed severe bradycardia followed by cardiac arrest. A 79-year-old male patient underwent an amputation of the right lower extremity. The electrocardiogram of the patient showed a complete right bundle branch block with left anterior fascicular block before the anesthesia, and paroxysmal atrial tachycardia over 200 beats/min lasting 15 min was observed during surgery. After admission to the intensive care unit, the intensivist and the consultant cardiologist decided to treat tachycardia using amiodarone. The initial dosing of amiodarone and the maintenance infusion succeeded to decrease the heart rate. Approximately 2 h and a half after the start of dexmedetomidine infusion for sedation, the heart rate gradually declined and severe bradycardia suddenly followed by cardiac arrest was observed. Resuscitation was promptly initiated and the patient regained sinus rhythm without delay. In retrospective analysis, the monitoring record of the electrocardiogram revealed the marked atrioventricular conduction abnormalities. This is the first case report concerning a cardiac arrest induced by amiodarone and dexmedetomidine.
ISSN:2052-0492
2052-0492
DOI:10.1186/s40560-015-0109-0