Monitoring the in vivo siRNA release from lipid nanoparticles based on the fluorescence resonance energy transfer principle

• Published in: Asian journal of pharmceutical sciences Vol. 18; no. 1; pp. 100769 - 85
• Main Authors: Sun, Lei, Zhang, Jinfang, Zhou, Jing-e, Wang, Jing, Wang, Zhehao, Luo, Shenggen, Wang, Yeying, Zhu, Shulei, Yang, Fan, Tang, Jie, Lu, Wei, Wang, Yiting, Yu, Lei, Yan, Zhiqiang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2023; Institute of Biomedical Engineering and Technology,Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development,School of Chemistry and Molecular Engineering,East China Normal University,Shanghai 200062,China%Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development,School of Chemistry and Molecular Engineering,East China Normal University,Shanghai 200062,China; Shenyang Pharmaceutical University; Elsevier
• Subjects: Fluorescence resonance energy transfer; In vivo release; Lipid nanoparticles; Nanogolds; Original Research Paper; Survivin siRNA; Survivin siRNA; Fluorescence resonance energy transfer; In vivo release; Nanogolds; Lipid nanoparticles

The siRNA-loaded lipid nanoparticles have attracted much attention due to its significant gene silencing effect and successful marketization. However, the in vivo distribution and release of siRNA still cannot be effectively monitored. In this study, based on the fluorescence resonance energy transf...