Carboxylesterases: structure, function and polymorphism in mammals

This review covers current developments in molecular-based studies of the structure and function of carboxylesterases. To allay the confusion of the classic classification of carboxylesterase isozymes, we propose a novel nomenclature and classification of mammalian carboxylesterases on the basis of...

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Bibliographic Details
Published inJournal of Pesticide Science Vol. 35; no. 3; pp. 218 - 228
Main Authors Satoh, Tetsuo, Hosokawa, Masakiyo
Format Journal Article
LanguageEnglish
Published Pesticide Science Society of Japan 01.01.2010
Subjects
carboxylesterase
classification
genetic polymorphism
molecular structure
novel biomarker
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Summary:This review covers current developments in molecular-based studies of the structure and function of carboxylesterases. To allay the confusion of the classic classification of carboxylesterase isozymes, we propose a novel nomenclature and classification of mammalian carboxylesterases on the basis of molecular properties. Mechanisms of the regulation of the gene expression of carboxylesterases by xenobiotics, and the involvement of carboxylesterase in drug metabolism are also described. The novel biomarker for organophosphate pesticide exposure developed here is much more useful and reliable than cholinesterase inhibition.
ISSN:1348-589X
1349-0923
DOI:10.1584/jpestics.R10-02