Modeling GABA Alterations in Schizophrenia: A Link Between Impaired Inhibition and Altered Gamma and Beta Range Auditory Entrainment

• Published in: Journal of neurophysiology Vol. 99; no. 5; pp. 2656 - 2671
• Main Authors: Vierling-Claassen, Dorea, Siekmeier, Peter, Stufflebeam, Steven, Kopell, Nancy
• Format: Journal Article
• Language: English
• Published: United States Am Phys Soc 01.05.2008
• Subjects: Acoustic Stimulation; Adolescent; Adult; Algorithms; Auditory Cortex - physiopathology; Auditory Perception - physiology; Beta Rhythm; Computer Simulation; Electroencephalography; Evoked Potentials - physiology; Excitatory Postsynaptic Potentials - physiology; GABA Plasma Membrane Transport Proteins - genetics; GABA Plasma Membrane Transport Proteins - metabolism; gamma-Aminobutyric Acid - physiology; Glutamate Decarboxylase - genetics; Glutamate Decarboxylase - metabolism; Humans; Interneurons - physiology; Magnetoencephalography; Male; Middle Aged; Models, Neurological; Neural Networks, Computer; Psychiatric Status Rating Scales; Schizophrenia - genetics; Schizophrenia - metabolism; Schizophrenia - physiopathology; Schizophrenic Psychology

1 Department of Mathematics and Statistics, 2 Center for BioDynamics, Boston University, Boston; 3 McLean Hospital, Harvard Medical School, Belmont; and 4 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts Submitted 6 August 2007; accepted...