Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion

• Published in: Journal of allergy and clinical immunology Vol. 132; no. 2; pp. 297 - 304.e3
• Main Authors: Nanzer, Alexandra M., Chambers, Emma S., Ryanna, Kimuli, Richards, David F., Black, Cheryl, Timms, Peter M., Martineau, Adrian R., Griffiths, Christopher J., Corrigan, Christopher J., Hawrylowicz, Catherine M.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.08.2013; Elsevier
• Subjects: Adult; Allergy and Immunology; antagonists; anti-inflammatory activity; Asthma; Asthma - drug therapy; Asthma - immunology; Asthma - physiopathology; Biological and medical sciences; Cells, Cultured; dexamethasone; Drug Resistance; enzyme-linked immunosorbent assay; Female; flow cytometry; Fundamental and applied biological sciences. Psychology; Fundamental immunology; glucocorticoids; Glucocorticoids - pharmacology; Glucocorticoids - therapeutic use; Humans; IL-17A; interleukin-10; Interleukin-10 - biosynthesis; Interleukin-10 - genetics; interleukin-17; Interleukin-17 - biosynthesis; Interleukin-17 - genetics; Interleukin-22; Interleukins - biosynthesis; Interleukins - genetics; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Lymphocyte Activation; Male; Medical sciences; mononuclear leukocytes; patients; quantitative polymerase chain reaction; Real-Time Polymerase Chain Reaction; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Severity of Illness Index; steroid resistant; steroid sensitive; steroids; TH17; Th17 Cells - immunology; Th17 Cells - metabolism; Up-Regulation; vitamin D; Vitamin D - analogs & derivatives; Vitamin D - pharmacology; Vitamin D - therapeutic use; SS; IL-17A; vitamin D; Treg; 1,25(OH)2D3; GR; Asthma; steroid resistant; steroid sensitive; glucocorticoids; Foxp3; TH17; SR; T H17; 1α,25-Dihydroxyvitamin D3; Forkhead box protein 3; Glucocorticoid receptor; Regulatory T; 1,25(OH) 2D3; Human; Steroid; Immunopathology; 17; Calcitriol; Cytokine; Biosynthesis; Glucocorticoid; Resistance; Immunology; Vitamin D; T; Inhibitor; Severe asthma; Th17 lymphocyte; 1,25(OH)D3; T(H)17; Steroid resistant; Steroid sensitive

TH17 cells are proposed to play a role in the pathology of asthma, including steroid-resistant (SR) disease. We previously identified a steroid-enhancing function of vitamin D in patients with SR asthma in restoring the impaired response to steroids for production of the anti-inflammatory cytokine I...