Postrelapse survival in childhood acute lymphoblastic leukemia is independent of initial treatment intensity: a report from the Children's Oncology Group

• Published in: Blood Vol. 117; no. 11; pp. 3010 - 3015
• Main Authors: Freyer, David R., Devidas, Meenakshi, La, Mei, Carroll, William L., Gaynon, Paul S., Hunger, Stephen P., Seibel, Nita L.
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 17.03.2011; Americain Society of Hematology; American Society of Hematology
• Subjects: Antineoplastic Agents - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Cause of Death; Child; Child, Preschool; Clinical Trials and Observations; Cohort Studies; Hematologic and hematopoietic diseases; Humans; Infant; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma - prevention & control; Recurrence; Survival Analysis; Treatment Outcome; Human; Cancerology; Treatment; Hematology; Lymphoproliferative syndrome; Intensity; Malignant hemopathy; Acute lymphocytic leukemia; Malignant tumor; Child; Survival; Cancer

While intensification of therapy has improved event-free survival (EFS) and survival in newly diagnosed children with acute lymphoblastic leukemia (ALL), postrelapse outcomes remain poor. It might be expected that patients relapsing after inferior initial therapy would have a higher retrieval rate t...