Retinoic acid regulates Kit translation during spermatogonial differentiation in the mouse

• Published in: Developmental biology Vol. 397; no. 1; pp. 140 - 149
• Main Authors: Busada, Jonathan T., Chappell, Vesna A., Niedenberger, Bryan A., Kaye, Evelyn P., Keiper, Brett D., Hogarth, Cathryn A., Geyer, Christopher B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2015
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Animals; Cell Differentiation; Cell Lineage; genes; linkage (genetics); longevity; Male; males; meiosis; messenger RNA; Mice; Mice, Inbred C57BL; Mice, Knockout; neoplasms; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-kit - metabolism; receptor protein-tyrosine kinase; Retinoic acid; Signal Transduction; Spermatogenesis; Spermatogonia; Spermatogonia - metabolism; spermatozoa; stem cells; testes; Testis; Testis - metabolism; TOR Serine-Threonine Kinases - metabolism; Translation; Tretinoin - metabolism; Testis; Translation; Spermatogenesis; Retinoic acid; Spermatogonia; Kit

In the testis, a subset of spermatogonia retains stem cell potential, while others differentiate to eventually become spermatozoa. This delicate balance must be maintained, as defects can result in testicular cancer or infertility. Currently, little is known about the gene products and signaling pat...