Altered mechanobiology of Schlemm’s canal endothelial cells in glaucoma

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 38; pp. 13876 - 13881
• Main Authors: Overby, Darryl R., Zhou, Enhua H., Vargas-Pinto, Rocio, Pedrigi, Ryan M., Fuchshofer, Rudolf, Braakman, Sietse T., Gupta, Ritika, Perkumas, Kristin M., Sherwood, Joseph M., Vahabikashi, Amir, Dang, Quynh, Kim, Jae Hun, Ethier, C. Ross, Stamer, W. Daniel, Fredberg, Jeffrey J., Johnson, Mark
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 23.09.2014; National Acad Sciences
• Subjects: Biological Sciences; Biomechanics; Canals; Cell culture; Cells; Cells, Cultured; Cytoskeleton - metabolism; Cytoskeleton - pathology; Delta cells; Density; Endothelial cells; Endothelial Cells - metabolism; Endothelial Cells - pathology; Endothelium; Eye - metabolism; Eye - pathology; Eyes; Gels; Gene expression; Glaucoma; Glaucoma - metabolism; Glaucoma - pathology; Humans; Microscopy, Atomic Force; Stiffness; Trabecular meshwork; primary open-angle glaucoma; cytoskeleton; cell mechanics; modulus

Increased flow resistance is responsible for the elevated intraocular pressure characteristic of glaucoma, but the cause of this resistance increase is not known. We tested the hypothesis that altered biomechanical behavior of Schlemm’s canal (SC) cells contributes to this dysfunction. We used atomi...