Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers

• Published in: Cancer cell Vol. 28; no. 4; pp. 529 - 540
• Main Authors: Yan, Xiaohui, Hu, Zhongyi, Feng, Yi, Hu, Xiaowen, Yuan, Jiao, Zhao, Sihai D., Zhang, Youyou, Yang, Lu, Shan, Weiwei, He, Qun, Fan, Lingling, Kandalaft, Lana E., Tanyi, Janos L., Li, Chunsheng, Yuan, Chao-Xing, Zhang, Dongmei, Yuan, Huiqing, Hua, Keqin, Lu, Yiling, Katsaros, Dionyssios, Huang, Qihong, Montone, Kathleen, Fan, Yi, Coukos, George, Boyd, Jeff, Sood, Anil K., Rebbeck, Timothy, Mills, Gordon B., Dang, Chi V., Zhang, Lin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.10.2015
• Subjects: Cell Line, Tumor; Computational Biology - methods; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Variation; Genome, Human; Humans; Neoplasms - genetics; RNA, Long Noncoding - genetics; Transcription, Genetic

The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas....