Probiotic helminth administration in relapsing–remitting multiple sclerosis: a phase 1 study

• Published in: Multiple sclerosis Vol. 17; no. 6; pp. 743 - 754
• Main Authors: Fleming, JO, Isaak, A, Lee, JE, Luzzio, CC, Carrithers, MD, Cook, TD, Field, AS, Boland, J, Fabry, Z
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.06.2011; Sage Publications Ltd
• Subjects: Administration, Oral; Adult; Animals; Antibodies, Helminth - blood; Autoimmune diseases; Biomarkers - blood; Brain - pathology; C-Reactive Protein - metabolism; Female; Humans; Hygiene; Immunomodulation; Inflammatory bowel diseases; Interleukin 10; Interleukin 4; Interleukin-10 - blood; Interleukin-4 - blood; Magnetic Resonance Imaging; Male; Multiple sclerosis; Multiple Sclerosis, Relapsing-Remitting - diagnosis; Multiple Sclerosis, Relapsing-Remitting - immunology; Multiple Sclerosis, Relapsing-Remitting - therapy; Ova; Pilot Projects; probiotics; Probiotics - adverse effects; Serum levels; Side effects; Time Factors; Treatment Outcome; Trichuris - immunology; Up-Regulation; Wisconsin; Young Adult; Wisconsin; immunomodulation; probiotic; hygiene hypothesis; multiple sclerosis; whipworm; cytokines; Trichuris

Background: Probiotic treatment strategy based on the hygiene hypothesis, such as administration of ova from the non-pathogenic helminth, Trichuris suis, (TSO) has proven safe and effective in autoimmune inflammatory bowel disease. Objective: To study the safety and effects of TSO in a second autoim...