Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses - Ho, Ping-Chih; Bihuniak, Jessica Dauz; Macintyre, Andrew N.; Staron, Matthew; Liu, Xiaojing; Amezquita, Robert; Tsui, Yao-Chen; Cui, Guoliang; Micevic, Goran; Perales, Jose C.; Kleinstein, Steven H.; Abel, E. Dale; et al. (Cell, 2015)
Keywords: Animals; Ca2-transporting ATPase; Calcium - metabolism; CD4-Positive T-Lymphocytes - immunology; CD8-positive T-lymphocytes; Endoplasmic Reticulum - metabolism; Glycolysis; Hexokinase - metabolism; Immunotherapy; Lymphocytes, Tumor-Infiltrating - immunology; Melanoma - immunology; Melanoma - therapy; metabolites; Mice; Monitoring, Immunologic; NFATC Transcription Factors - metabolism; Phosphoenolpyruvate - metabolism; Receptors, Antigen, T-Cell - metabolism; Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism; Signal Transduction; Transforming Growth Factor beta - immunology; Tumor Microenvironment