Ex vivo expansion of human hematopoietic stem and progenitor cells

• Published in: Blood Vol. 117; no. 23; pp. 6083 - 6090
• Main Authors: Dahlberg, Ann, Delaney, Colleen, Bernstein, Irwin D.
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 09.06.2011; Americain Society of Hematology; American Society of Hematology
• Subjects: Biological and medical sciences; Cell Culture Techniques - methods; Cytokines - pharmacology; Fetal Blood - cytology; Fetal Blood - metabolism; Hematologic and hematopoietic diseases; Hematopoiesis and Stem Cells; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Humans; Medical sciences; Receptors, Notch - metabolism; Review; Signal Transduction - drug effects; Human; Hematopoietic cell; Ex vivo; Hematology; Expansion; Stem cell

Despite progress in our understanding of the growth factors that support the progressive maturation of the various cell lineages of the hematopoietic system, less is known about factors that govern the self-renewal of hematopoietic stem and progenitor cells (HSPCs), and our ability to expand human H...