Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 29; pp. 10684 - 10689
• Main Authors: Zhang, Ping, Tu, Bo, Wang, Hua, Cao, Ziyang, Tang, Ming, Zhang, Chaohua, Gu, Bo, Li, Zhiming, Wang, Lina, Yang, Yang, Zhao, Ying, Wang, Haiying, Luo, Jianyuan, Deng, Chu-Xia, Gao, Bin, Roeder, Robert G., Zhu, Wei-Guo
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 22.07.2014; National Acad Sciences
• Subjects: Acetylation; Animals; Antibodies; Biological Sciences; Blood Glucose - metabolism; Cell lines; Cell nucleus; Cell Nucleus - metabolism; Cellular immunity; Cytoplasm; Down regulation; Down-Regulation - genetics; Enzymes; Forkhead Box Protein O1; Forkhead Transcription Factors - metabolism; Gene expression regulation; Gluconeogenesis; Gluconeogenesis - genetics; Glucose; glucose-6-phosphatase; Glucose-6-Phosphatase - genetics; Glucose-6-Phosphatase - metabolism; glycolysis; HCT116 Cells; Hep G2 cells; histone deacetylase; Humans; knockout mutants; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; NAD (coenzyme); oxidative phosphorylation; Phosphoenolpyruvate Carboxykinase (ATP) - genetics; Phosphoenolpyruvate Carboxykinase (ATP) - metabolism; Phosphorylation; Plasmids; Protein Binding; Protein expression; Protein Transport; Sirtuins - genetics; Sirtuins - metabolism; transcription factors; Transcription, Genetic; Tumor Suppressor Protein p53 - metabolism; Tumors

In mammalian cells, tumor suppressor p53 plays critical roles in the regulation of glucose metabolism, including glycolysis and oxidative phosphorylation, but whether and how p53 also regulates gluconeogenesis is less clear. Here, we report that p53 efficiently down-regulates the expression of phosp...