Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion - Zhang, Ping; Tu, Bo; Wang, Hua; Cao, Ziyang; Tang, Ming; Zhang, Chaohua; Gu, Bo; Li, Zhiming; Wang, Lina; Yang, Yang; Zhao, Ying; Wang, Haiying; et al. (Proceedings of the National Academy of Sciences - PNAS, 2014)
Keywords: Acetylation; Animals; Antibodies; Biological Sciences; Blood Glucose - metabolism; Cell lines; Cell nucleus; Cell Nucleus - metabolism; Cellular immunity; Cytoplasm; Down regulation; Down-Regulation - genetics; Enzymes; Forkhead Box Protein O1; Forkhead Transcription Factors - metabolism; Gene expression regulation; Gluconeogenesis; Gluconeogenesis - genetics; Glucose; glucose-6-phosphatase; Glucose-6-Phosphatase - genetics; Glucose-6-Phosphatase - metabolism; glycolysis; HCT116 Cells; Hep G2 cells; histone deacetylase; Humans; knockout mutants; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; NAD (coenzyme); oxidative phosphorylation; Phosphoenolpyruvate Carboxykinase (ATP) - genetics; Phosphoenolpyruvate Carboxykinase (ATP) - metabolism; Phosphorylation; Plasmids; Protein Binding; Protein expression; Protein Transport; Sirtuins - genetics; Sirtuins - metabolism; transcription factors; Transcription, Genetic; Tumor Suppressor Protein p53 - metabolism; Tumors