Natural killer cell immunotypes related to COVID-19 disease severity

• Published in: Science immunology Vol. 5; no. 50
• Main Authors: Maucourant, Christopher, Filipovic, Iva, Ponzetta, Andrea, Aleman, Soo, Cornillet, Martin, Hertwig, Laura, Strunz, Benedikt, Lentini, Antonio, Reinius, Björn, Brownlie, Demi, Cuapio, Angelica, Ask, Eivind Heggernes, Hull, Ryan M, Haroun-Izquierdo, Alvaro, Schaffer, Marie, Klingström, Jonas, Folkesson, Elin, Buggert, Marcus, Sandberg, Johan K, Eriksson, Lars I, Rooyackers, Olav, Ljunggren, Hans-Gustaf, Malmberg, Karl-Johan, Michaëlsson, Jakob, Marquardt, Nicole, Hammer, Quirin, Strålin, Kristoffer, Björkström, Niklas K
• Format: Journal Article
• Language: English
• Published: United States 21.08.2020
• Subjects: Adaptive Immunity; Betacoronavirus - genetics; Betacoronavirus - immunology; CD56 Antigen - metabolism; Coronavirus Infections - blood; Coronavirus Infections - epidemiology; Coronavirus Infections - immunology; Coronavirus Infections - pathology; COVID-19; Female; Flow Cytometry - methods; Humans; Killer Cells, Natural - immunology; Lymphocyte Activation; Male; Middle Aged; Pandemics; Phenotype; Pneumonia, Viral - blood; Pneumonia, Viral - epidemiology; Pneumonia, Viral - immunology; Pneumonia, Viral - pathology; Polymerase Chain Reaction; Prospective Studies; Protein Interaction Maps - immunology; Receptors, KIR - metabolism; SARS-CoV-2; Serologic Tests; Severity of Illness Index; Sweden - epidemiology; Sweden

Understanding innate immune responses in COVID-19 is important to decipher mechanisms of host responses and interpret disease pathogenesis. Natural killer (NK) cells are innate effector lymphocytes that respond to acute viral infections but might also contribute to immunopathology. Using 28-color fl...