Is ageing associated with a shift in the balance between Type 1 and Type 2 cytokines in humans?
SUMMARY The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and mortality from infectious diseases, this study tests if ageing is associated with a change towards Type 2 dominance in T cells. Expressi...
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| Published in | Clinical and experimental immunology Vol. 127; no. 1; pp. 107 - 114 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Science Ltd
01.01.2002
Blackwell Oxford University Press Blackwell Science Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-9104 1365-2249 |
| DOI | 10.1046/j.1365-2249.2002.01736.x |
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| Abstract | SUMMARY
The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and mortality from infectious diseases, this study tests if ageing is associated with a change towards Type 2 dominance in T cells. Expression of IFN‐γ, and IL‐4 was measured in CD4+ and CD8+ T cells by flow cytometry in three groups: young controls (n = 28), 81‐year‐olds (n = 22), and centenarians (n = 25). The major findings were that the percentage of IFN‐γ+ as well as IL‐4+ T cells was increased in aged subjects. Furthermore, after adjusting for decreased lymphocyte counts in the elderly, the concentration in the blood of IFN‐γ+ and IL‐4+ CD8+ T cells was still increased in the 81‐year‐olds. In centenarians, a shift towards a relative dominance of Type 2 cytokine expression was found within CD8+ T cells. Furthermore, the percentage of T cells with cytokine expression was closely correlated to the in vivo expression of CD95 and CD45RO. In conclusion, we found some evidence for an age‐related shift towards a Type 2 cytokine profile. |
|---|---|
| AbstractList | The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and mortality from infectious diseases, this study tests if ageing is associated with a change towards Type 2 dominance in T cells. Expression of IFN-γ, and IL-4 was measured in CD4
+
and CD8
+
T cells by flow cytometry in three groups: young controls (n = 28), 81-year-olds (n = 22), and centenarians (n = 25). The major findings were that the percentage of IFN-γ
+
as well as IL-4
+
T cells was increased in aged subjects. Furthermore, after adjusting for decreased lymphocyte counts in the elderly, the concentration in the blood of IFN-γ
+
and IL-4
+
CD8
+
T cells was still increased in the 81-year-olds. In centenarians, a shift towards a relative dominance of Type 2 cytokine expression was found within CD8
+
T cells. Furthermore, the percentage of T cells with cytokine expression was closely correlated to the in vivo expression of CD95 and CD45RO. In conclusion, we found some evidence for an age-related shift towards a Type 2 cytokine profile. The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and mortality from infectious diseases, this study tests if ageing is associated with a change towards Type 2 dominance in T cells. Expression of IFN- gamma , and IL-4 was measured in CD4 super(+) and CD8 super(+) T cells by flow cytometry in three groups: young controls (n = 28), 81-year-olds (n = 22), and centenarians (n = 25). The major findings were that the percentage of IFN- gamma super(+) as well as IL-4 super(+) T cells was increased in aged subjects. Furthermore, after adjusting for decreased lymphocyte counts in the elderly, the concentration in the blood of IFN- gamma super(+) and IL-4 super(+) CD8 super(+) T cells was still increased in the 81-year-olds. In centenarians, a shift towards a relative dominance of Type 2 cytokine expression was found within CD8 super(+) T cells. Furthermore, the percentage of T cells with cytokine expression was closely correlated to the in vivo expression of CD95 and CD45RO. In conclusion, we found some evidence for an age-related shift towards a Type 2 cytokine profile. The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and mortality from infectious diseases, this study tests if ageing is associated with a change towards Type 2 dominance in T cells. Expression of IFN-gamma, and IL-4 was measured in CD4+ and CD8+ T cells by flow cytometry in three groups: young controls (n=28), 81-year-olds (n=22), and centenarians (n=25). The major findings were that the percentage of IFN-gamma+ as well as IL-4+ T cells was increased in aged subjects. Furthermore, after adjusting for decreased lymphocyte counts in the elderly, the concentration in the blood of IFN-gamma+ and IL-4+ CD8+ T cells was still increased in the 81-year-olds. In centenarians, a shift towards a relative dominance of Type 2 cytokine expression was found within CD8+ T cells. Furthermore, the percentage of T cells with cytokine expression was closely correlated to the in vivo expression of CD95 and CD45RO. In conclusion, we found some evidence for an age-related shift towards a Type 2 cytokine profile.The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and mortality from infectious diseases, this study tests if ageing is associated with a change towards Type 2 dominance in T cells. Expression of IFN-gamma, and IL-4 was measured in CD4+ and CD8+ T cells by flow cytometry in three groups: young controls (n=28), 81-year-olds (n=22), and centenarians (n=25). The major findings were that the percentage of IFN-gamma+ as well as IL-4+ T cells was increased in aged subjects. Furthermore, after adjusting for decreased lymphocyte counts in the elderly, the concentration in the blood of IFN-gamma+ and IL-4+ CD8+ T cells was still increased in the 81-year-olds. In centenarians, a shift towards a relative dominance of Type 2 cytokine expression was found within CD8+ T cells. Furthermore, the percentage of T cells with cytokine expression was closely correlated to the in vivo expression of CD95 and CD45RO. In conclusion, we found some evidence for an age-related shift towards a Type 2 cytokine profile. The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and mortality from infectious diseases, this study tests if ageing is associated with a change towards Type 2 dominance in T cells. Expression of IFN-gamma, and IL-4 was measured in CD4+ and CD8+ T cells by flow cytometry in three groups: young controls (n=28), 81-year-olds (n=22), and centenarians (n=25). The major findings were that the percentage of IFN-gamma+ as well as IL-4+ T cells was increased in aged subjects. Furthermore, after adjusting for decreased lymphocyte counts in the elderly, the concentration in the blood of IFN-gamma+ and IL-4+ CD8+ T cells was still increased in the 81-year-olds. In centenarians, a shift towards a relative dominance of Type 2 cytokine expression was found within CD8+ T cells. Furthermore, the percentage of T cells with cytokine expression was closely correlated to the in vivo expression of CD95 and CD45RO. In conclusion, we found some evidence for an age-related shift towards a Type 2 cytokine profile. SUMMARY The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and mortality from infectious diseases, this study tests if ageing is associated with a change towards Type 2 dominance in T cells. Expression of IFN‐γ, and IL‐4 was measured in CD4+ and CD8+ T cells by flow cytometry in three groups: young controls (n = 28), 81‐year‐olds (n = 22), and centenarians (n = 25). The major findings were that the percentage of IFN‐γ+ as well as IL‐4+ T cells was increased in aged subjects. Furthermore, after adjusting for decreased lymphocyte counts in the elderly, the concentration in the blood of IFN‐γ+ and IL‐4+ CD8+ T cells was still increased in the 81‐year‐olds. In centenarians, a shift towards a relative dominance of Type 2 cytokine expression was found within CD8+ T cells. Furthermore, the percentage of T cells with cytokine expression was closely correlated to the in vivo expression of CD95 and CD45RO. In conclusion, we found some evidence for an age‐related shift towards a Type 2 cytokine profile. The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and mortality from infectious diseases, this study tests if ageing is associated with a change towards Type 2 dominance in T cells. Expression of IFN-γ, and IL-4 was measured in CD4+ and CD8+ T cells by flow cytometry in three groups: young controls (n = 28), 81-year-olds (n = 22), and centenarians (n = 25). The major findings were that the percentage of IFN-γ+ as well as IL-4+ T cells was increased in aged subjects. Furthermore, after adjusting for decreased lymphocyte counts in the elderly, the concentration in the blood of IFN-γ+ and IL-4+ CD8+ T cells was still increased in the 81-year-olds. In centenarians, a shift towards a relative dominance of Type 2 cytokine expression was found within CD8+ T cells. Furthermore, the percentage of T cells with cytokine expression was closely correlated to the in vivo expression of CD95 and CD45RO. In conclusion, we found some evidence for an age-related shift towards a Type 2 cytokine profile. |
| Author | Skinhøj, P. Kemp, K. Bruunsgaard, H. Sandmand, M. Andersen‐Ranberg, K. Pedersen, A. N. |
| Author_xml | – sequence: 1 givenname: M. surname: Sandmand fullname: Sandmand, M. – sequence: 2 givenname: H. surname: Bruunsgaard fullname: Bruunsgaard, H. – sequence: 3 givenname: K. surname: Kemp fullname: Kemp, K. – sequence: 4 givenname: K. surname: Andersen‐Ranberg fullname: Andersen‐Ranberg, K. – sequence: 5 givenname: A. N. surname: Pedersen fullname: Pedersen, A. N. – sequence: 6 givenname: P. surname: Skinhøj fullname: Skinhøj, P. |
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The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity... The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and... |
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| SubjectTerms | Adult Aged Aged, 80 and over ageing Aging - immunology Antigens, CD - immunology Biological and medical sciences CD4 antigen CD8 antigen CD95 Clinical Studies Cytokines - biosynthesis Cytokines - immunology Female Fundamental and applied biological sciences. Psychology Fundamental immunology g-Interferon Humans IFN‐γ IL‐4 Immunity, Cellular - physiology Immunobiology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Male Middle Aged Th1 Cells - immunology Th1/Th2 ratio Th2 Cells - immunology |
| Title | Is ageing associated with a shift in the balance between Type 1 and Type 2 cytokines in humans? |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1046%2Fj.1365-2249.2002.01736.x https://www.ncbi.nlm.nih.gov/pubmed/11882040 https://www.proquest.com/docview/196867066 https://www.proquest.com/docview/18279757 https://www.proquest.com/docview/71503554 https://pubmed.ncbi.nlm.nih.gov/PMC1906284 |
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