Genetic characterization of hemagglutinin protein of measles viruses in Hokkaido district, Japan, 2006-2015

The strains of measles virus, genotypes D5, H1, D4, D8, and B3, were detected among an epidemic, endemic, imported, or import-associated cases in Hokkaido district, Japan, during 2006-2015. In the present study, to evaluate the antigenic features, we determined the complete nucleotide sequences of t...

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Published inMicrobiology and immunology
Main Authors Miyoshi, Masahiro, Komagome, Rika, Yamaguchi, Hiroki, Ishida, Setsuko, Nagano, Hideki, Okano, Motohiko
Format Journal Article
LanguageEnglish
Published Australia 01.06.2018
Subjects
hemagglutinin
Hokkaido
measles virus
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Abstract The strains of measles virus, genotypes D5, H1, D4, D8, and B3, were detected among an epidemic, endemic, imported, or import-associated cases in Hokkaido district, Japan, during 2006-2015. In the present study, to evaluate the antigenic features, we determined the complete nucleotide sequences of the hemagglutinin protein, which is a major target for neutralizing antibodies, and deduced the amino acid sequences. Our results demonstrated that the hemagglutinin proteins of these strains had several novel amino acid changes in some functional regions. Although these strains have not caused further occurrence at present, we should monitor the antigenic changes in future to maintain the elimination status.
AbstractList The strains of measles virus, genotypes D5, H1, D4, D8, and B3, were detected among an epidemic, endemic, imported, or import-associated cases in Hokkaido district, Japan, during 2006-2015. In the present study, to evaluate the antigenic features, we determined the complete nucleotide sequences of the hemagglutinin protein, which is a major target for neutralizing antibodies, and deduced the amino acid sequences. Our results demonstrated that the hemagglutinin proteins of these strains had several novel amino acid changes in some functional regions. Although these strains have not caused further occurrence at present, we should monitor the antigenic changes in future to maintain the elimination status.
Author Ishida, Setsuko
Nagano, Hideki
Komagome, Rika
Okano, Motohiko
Yamaguchi, Hiroki
Miyoshi, Masahiro
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  surname: Okano
  fullname: Okano, Motohiko
  organization: Hokkaido Institute of Public Health, North 19 West 12, Kita-ku, Sapporo 060-0819, Japan
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Keywords hemagglutinin
Hokkaido
measles virus
Language English
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Title Genetic characterization of hemagglutinin protein of measles viruses in Hokkaido district, Japan, 2006-2015
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