Nine genes abundantly expressed in the epididymis are not essential for male fecundity in mice

• Published in: Andrology (Oxford) Vol. 7; no. 5; pp. 644 - 653
• Main Authors: Noda, T., Sakurai, N., Nozawa, K., Kobayashi, S., Devlin, D. J., Matzuk, M. M., Ikawa, M.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.09.2019; John Wiley and Sons Inc
• Subjects: CRISPR; genetically modified mice; genome editing; Histology; Males; Mutation; Original; Sperm; sperm maturation; genome editing; genetically modified mice; sperm maturation

Background Spermatozoa become competent for fertilization during transit through the epididymis. As spermatozoa from the proximal caudal epididymis can fertilize eggs, proteins from the caput and corpus epididymis are required for sperm maturation. Objectives Microarray analysis identified that more...