Effects of Simvastatin on the Metabolism of Vonoprazan in Rats Both in vitro and in vivo

• Published in: Drug Design, Development and Therapy Vol. 16; pp. 1779 - 1789
• Main Authors: Hong, Yun, Dai, Da-Peng, Cai, Jian-Ping, Wang, Shuang-Hu, Wang, Yi-Ran, Zhao, Fang-Ling, Zhou, Shan, Zhou, Quan, Geng, Pei-Wu, Zhou, Yun-Fang, Xu, Xue, Shi, Ji-Hua, Luo, Qing-Feng
• Format: Journal Article
• Language: English
• Published: New Zealand Informa UK Limited 01.06.2022; Dove Medical Press Limited; Dove; Dove Medical Press
• Subjects: Animal experimentation; Animals; Antilipemic agents; Chromatography, Liquid; Drug Design, Development and Therapy; Drug Interactions; drug-drug interactions; liquid chromatography-tandem mass spectrometry; Liver; Mass spectrometry; Metabolites; Microsomes, Liver; Original Research; Pyrroles; rat liver microsomes; Rats; Rats, Sprague-Dawley; Simvastatin; Sulfonamides; Tandem Mass Spectrometry; vonoprazan; China; liquid chromatography-tandem mass spectrometry; simvastatin; rat liver microsomes; vonoprazan; drug–drug interactions

To study the potential drug-drug interactions between simvastatin and vonoprazan and to provide the scientific basis for rational use of them in clinical practice. An incubation system was established with rat liver microsomes, and the main metabolite of vonoprazan M-I was detected by UPLC-MS/MS. Th...