Selenomethionine Alleviates Deoxynivalenol-Induced Oxidative Injury in Porcine Intestinal Epithelial Cells Independent of MAPK Pathway Regulation

• Published in: Antioxidants Vol. 13; no. 3; p. 356
• Main Authors: Huang, Zhouyin, Zhong, Haopeng, Li, Ting, Wang, Zirui, Chen, Xingping, Zou, Tiande, You, Jinming, Chen, Jun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.03.2024; MDPI
• Subjects: Cell growth; Cell proliferation; cytotoxicity; Deoxynivalenol; Epithelial cells; epithelium; Extracellular signal-regulated kinase; Feeds; Food contamination; Gene expression; genes; Health aspects; Hogs; Intestine; intestines; Kinases; L-Lactate dehydrogenase; lactate dehydrogenase; MAP kinase; MAPK pathway; mRNA; oxidative injury; Oxidative stress; oxidative toxicity; porcine intestinal epithelial cells; protein synthesis; Reactive oxygen species; RNA; Selenomethionine; Swine; Toxicity; China; Grand Island; United States > US; MAPK pathway; deoxynivalenol; selenomethionine; oxidative injury; porcine intestinal epithelial cells

Deoxynivalenol (DON) is a prevalent contaminant in feed and food, posing a serious threat to the health of both humans and animals. The pig stands as an ideal subject for the study of DON due to its recognition as the most susceptible animal to DON. In this study, the IPEC-J2 cells were utilized as...