The Nuclear Receptor Corepressor (NCoR) Controls Thyroid Hormone Sensitivity and the Set Point of the Hypothalamic-Pituitary-Thyroid Axis

• Published in: Molecular endocrinology (Baltimore, Md.) Vol. 25; no. 2; pp. 212 - 224
• Main Authors: Astapova, Inna, Vella, Kristen R, Ramadoss, Preeti, Holtz, Kaila A, Rodwin, Benjamin A, Liao, Xiao-Hui, Weiss, Roy E, Rosenberg, Michael A, Rosenzweig, Anthony, Hollenberg, Anthony N
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.02.2011; Oxford University Press
• Subjects: Animals; Blotting, Western; Gene Expression; Hypothalamo-Hypophyseal System - metabolism; Hypothyroidism; In Situ Hybridization; Mice; Mutant Proteins - metabolism; Nuclear Receptor Co-Repressor 1 - genetics; Nuclear Receptor Co-Repressor 1 - metabolism; Original Research; Polymerase Chain Reaction; Receptors, Thyroid Hormone - genetics; Receptors, Thyroid Hormone - metabolism; Thyroid Gland - metabolism; Thyroid Hormones - metabolism; Thyrotropin - blood; Thyroxine - blood; Triiodothyronine - blood

In vivo ablation of the interaction between NCoR and the TR leads to increased peripheral sensitivity to thyroid hormone and resets the HPT axis. The role of nuclear receptor corepressor (NCoR) in thyroid hormone (TH) action has been difficult to discern because global deletion of NCoR is embryonic...