Circulating miR-125b as a biomarker of Alzheimer's disease

• Published in: Journal of the neurological sciences Vol. 336; no. 1-2; pp. 52 - 56
• Main Authors: Tan, Lin, Yu, Jin-Tai, Liu, Qiu-Yan, Tan, Meng-Shan, Zhang, Wei, Hu, Nan, Wang, Ying-Li, Sun, Lei, Jiang, Teng, Tan, Lan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2014
• Subjects: Aged; Alzheimer Disease - blood; Alzheimer Disease - diagnosis; Alzheimer Disease - genetics; Alzheimer's disease; Biomarker; Biomarkers - blood; Cohort Studies; Diagnosis; Down-Regulation - genetics; Female; Humans; Male; MicroRNA; MicroRNAs - blood; MicroRNAs - genetics; Neurology; qRT-PCR; Serum; Serum; Biomarker; MicroRNA; Diagnosis; Alzheimer's disease; qRT-PCR

MicroRNAs (miRNAs) are endogenous small RNAs of 21–25 nucleotides that post-transcriptionally regulate gene expressions. Recently, circulating miRNAs have been reported as promising biomarkers for neurodegenerative disorders and processes affecting the central nervous system. This study was conducte...