Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits

A balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical processing. In line with this idea, the E/I balance is reportedly comparable across neighboring neurons, behavioral states, and developmental stages and...

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Published inNeuron (Cambridge, Mass.) Vol. 105; no. 4; pp. 621 - 629.e4
Main Authors Bridi, Michelle C.D., Zong, Fang-Jiao, Min, Xia, Luo, Nancy, Tran, Trinh, Qiu, Jiaqian, Severin, Daniel, Zhang, Xue-Ting, Wang, Guanglin, Zhu, Zheng-Jiang, He, Kai-Wen, Kirkwood, Alfredo
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 19.02.2020
Elsevier Limited
Subjects
Animals
Circadian Rhythm - physiology
Circuits
Developmental stages
Excitatory Postsynaptic Potentials - physiology
Female
Hippocampus
Inhibitory Postsynaptic Potentials - physiology
Light
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nerve Net - cytology
Nerve Net - physiology
Neural Inhibition - physiology
Neurological diseases
Organ Culture Techniques
Pyramidal cells
Pyramidal Cells - physiology
Sleep
Visual cortex
Visual Cortex - cytology
Visual Cortex - physiology
Visual pathways
Visual Pathways - cytology
Visual Pathways - physiology
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Abstract A balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical processing. In line with this idea, the E/I balance is reportedly comparable across neighboring neurons, behavioral states, and developmental stages and altered in many neurological disorders. Motivated by these ideas, we examined whether synaptic inhibition changes over the 24-h day to compensate for the well-documented sleep-dependent changes in synaptic excitation. We found that, in pyramidal cells of visual and prefrontal cortices and hippocampal CA1, synaptic inhibition also changes over the 24-h light/dark cycle but, surprisingly, in the opposite direction of synaptic excitation. Inhibition is upregulated in the visual cortex during the light phase in a sleep-dependent manner. In the visual cortex, these changes in the E/I balance occurred in feedback, but not feedforward, circuits. These observations open new and interesting questions on the function and regulation of the E/I balance. •The excitation/inhibition (E/I) ratio is dynamic across the 24-h day•Fluctuations in the E/I ratio depend on sleep/wake history•E/I ratio changes are circuit specific, not uniform across all synapses Bridi et al. investigate whether inhibition tracks known changes in excitation over the 24-h day to maintain a stable excitation/inhibition ratio. Surprisingly, the excitation/inhibition ratio is dynamic over the day in feedback, but not feedforward, visual cortical circuits.
AbstractList SummaryA balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical processing. In line with this idea, the E/I balance is reportedly comparable across neighboring neurons, behavioral states, and developmental stages and altered in many neurological disorders. Motivated by these ideas, we examined whether synaptic inhibition changes over the 24-h day to compensate for the well-documented sleep-dependent changes in synaptic excitation. We found that, in pyramidal cells of visual and prefrontal cortices and hippocampal CA1, synaptic inhibition also changes over the 24-h light/dark cycle but, surprisingly, in the opposite direction of synaptic excitation. Inhibition is upregulated in the visual cortex during the light phase in a sleep-dependent manner. In the visual cortex, these changes in the E/I balance occurred in feedback, but not feedforward, circuits. These observations open new and interesting questions on the function and regulation of the E/I balance.
A balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical processing. In line with this idea, the E/I balance is reportedly comparable across neighboring neurons, behavioral states, and developmental stages and altered in many neurological disorders. Motivated by these ideas, we examined whether synaptic inhibition changes over the 24-h day to compensate for the well-documented sleep-dependent changes in synaptic excitation. We found that, in pyramidal cells of visual and prefrontal cortices and hippocampal CA1, synaptic inhibition also changes over the 24-h light/dark cycle but, surprisingly, in the opposite direction of synaptic excitation. Inhibition is upregulated in the visual cortex during the light phase in a sleep-dependent manner. In the visual cortex, these changes in the E/I balance occurred in feedback, but not feedforward, circuits. These observations open new and interesting questions on the function and regulation of the E/I balance. •The excitation/inhibition (E/I) ratio is dynamic across the 24-h day•Fluctuations in the E/I ratio depend on sleep/wake history•E/I ratio changes are circuit specific, not uniform across all synapses Bridi et al. investigate whether inhibition tracks known changes in excitation over the 24-h day to maintain a stable excitation/inhibition ratio. Surprisingly, the excitation/inhibition ratio is dynamic over the day in feedback, but not feedforward, visual cortical circuits.
A balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical processing. In line with this idea, the E/I balance is reportedly comparable across neighboring neurons, behavioral states, and developmental stages and altered in many neurological disorders. Motivated by these ideas, we examined whether synaptic inhibition changes over the 24-h day to compensate for the well-documented sleep-dependent changes in synaptic excitation. We found that, in pyramidal cells of visual and prefrontal cortices and hippocampal CA1, synaptic inhibition also changes over the 24-h light/dark cycle but, surprisingly, in the opposite direction of synaptic excitation. Inhibition is upregulated in the visual cortex during the light phase in a sleep-dependent manner. In the visual cortex, these changes in the E/I balance occurred in feedback, but not feedforward, circuits. These observations open new and interesting questions on the function and regulation of the E/I balance.A balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical processing. In line with this idea, the E/I balance is reportedly comparable across neighboring neurons, behavioral states, and developmental stages and altered in many neurological disorders. Motivated by these ideas, we examined whether synaptic inhibition changes over the 24-h day to compensate for the well-documented sleep-dependent changes in synaptic excitation. We found that, in pyramidal cells of visual and prefrontal cortices and hippocampal CA1, synaptic inhibition also changes over the 24-h light/dark cycle but, surprisingly, in the opposite direction of synaptic excitation. Inhibition is upregulated in the visual cortex during the light phase in a sleep-dependent manner. In the visual cortex, these changes in the E/I balance occurred in feedback, but not feedforward, circuits. These observations open new and interesting questions on the function and regulation of the E/I balance.
A dynamic balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical processing. In line with this idea, measures of the E/I balance are reportedly comparable across neighboring neurons, across behavioral states and developmental stages, and altered in mouse models of autism and schizophrenia. Motivated by these ideas, we examined whether synaptic inhibition changes over the 24-hour day to compensate for the well-documented sleep-dependent changes in synaptic excitation. We found that in pyramidal cells of visual and prefrontal cortices as well as in hippocampal CA1, the strength of synaptic inhibition also changes over the 24h light/dark cycle, but surprisingly, in the opposite direction of synaptic excitation. The upregulation of inhibition in visual cortex during the light phase is sleep-dependent. Notably, in visual cortex, these changes in the E/I balance were observed in feedback, but not feedforward, circuits. The observations that the E/I balance is not constant but oscillates over the course of the day, and only in specific circuits, opens new and interesting questions on the function and regulation of the E/I balance.
A balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical processing. In line with this idea, the E/I balance is reportedly comparable across neighboring neurons, behavioral states, and developmental stages and altered in many neurological disorders. Motivated by these ideas, we examined whether synaptic inhibition changes over the 24-h day to compensate for the well-documented sleep-dependent changes in synaptic excitation. We found that, in pyramidal cells of visual and prefrontal cortices and hippocampal CA1, synaptic inhibition also changes over the 24-h light/dark cycle but, surprisingly, in the opposite direction of synaptic excitation. Inhibition is upregulated in the visual cortex during the light phase in a sleep-dependent manner. In the visual cortex, these changes in the E/I balance occurred in feedback, but not feedforward, circuits. These observations open new and interesting questions on the function and regulation of the E/I balance.
Author Wang, Guanglin
Zong, Fang-Jiao
Min, Xia
Severin, Daniel
Kirkwood, Alfredo
Bridi, Michelle C.D.
Tran, Trinh
Qiu, Jiaqian
Zhang, Xue-Ting
Luo, Nancy
Zhu, Zheng-Jiang
He, Kai-Wen
AuthorAffiliation 2. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
1. Mind/Brain Institute and Department of Neuroscience, Johns Hopkins University, Baltimore
3. University of Chinese Academy of Sciences, Beijing, China
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Cites_doi 10.1038/srep33661
10.1016/j.cub.2016.08.035
10.3389/fnsys.2017.00017
10.1016/j.neuron.2005.01.046
10.1038/nn.4137
10.3389/fncir.2018.00037
10.1038/nn.3701
10.1016/j.conb.2017.02.003
10.1073/pnas.0506071102
10.1038/nn2035
10.1016/0006-8993(90)91223-4
10.1007/s00018-003-3453-5
10.1038/nrn3136
10.1126/science.1166673
10.1073/pnas.1705841114
10.1016/j.neuron.2013.03.017
10.1016/j.neuron.2018.12.026
10.1523/JNEUROSCI.1409-10.2010
10.1098/rstb.2016.0156
10.3389/fncel.2018.00213
10.1016/j.celrep.2016.01.061
10.1016/j.biopsych.2016.12.006
10.1152/jn.00641.2011
10.1073/pnas.1510583112
10.1126/science.1211095
10.1038/nature11628
10.1146/annurev-neuro-071714-034002
10.1016/j.neuron.2016.02.040
10.1016/j.neuron.2017.05.016
10.1113/jphysiol.2003.058198
10.1016/j.neuron.2015.03.014
10.1016/j.neuron.2014.01.016
10.1016/S0896-6273(03)00814-6
10.1038/nature13321
10.1038/nature10360
10.1152/jn.00351.2004
10.1126/science.1146221
10.1523/JNEUROSCI.4975-14.2015
10.1016/j.neuron.2015.07.033
10.1098/rstb.2015.0429
10.1002/hipo.22360
10.5665/sleep.5546
10.1016/j.neuron.2015.09.037
10.1126/science.aah5982
10.1038/nature11356
10.1016/0006-8993(88)91440-0
10.1152/jn.1999.81.4.1559
10.1038/nn.2934
10.1016/j.neuron.2018.03.017
10.1016/j.lfs.2005.12.028
10.1523/JNEUROSCI.0083-18.2018
10.1007/s00429-017-1466-3
10.1002/hipo.22718
10.1126/science.aai8355
10.1016/j.neuron.2011.09.027
10.1016/j.neuron.2012.03.036
10.1523/JNEUROSCI.22-18-08084.2002
10.1523/JNEUROSCI.1666-15.2015
10.1007/s11306-017-1304-x
10.1016/j.neuron.2013.12.025
10.1152/jn.01037.2002
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References Trettel, Levine (bib50) 2003; 89
Rubin, Abbott, Sompolinsky (bib44) 2017; 114
Diering, Nirujogi, Roth, Worley, Pandey, Huganir (bib17) 2017; 355
Tao, Poo (bib49) 2005; 45
Chellappa, Gaggioni, Ly, Papachilleos, Borsu, Brzozowski, Rosanova, Sarasso, Luxen, Middleton (bib8) 2016; 6
Trettel, Fortin, Levine (bib51) 2004; 556
Petrus, Rodriguez, Patterson, Connor, Kanold, Lee (bib41) 2015; 35
Sadowski, Jones, Mellor (bib45) 2016; 14
Busche, Konnerth (bib4) 2016; 371
Gao, Whitt, Huang, Lee, Mihalas, Kirkwood, Lee (bib22) 2017; 372
Isaacson, Scanziani (bib28) 2011; 72
Tu, Yin, Xu, Wang, Zhu (bib52) 2017; 14
Valenti, Viganò, Casico, Rubino, Steardo, Parolaro, Di Marzo (bib53) 2004; 61
Tabuchi, Blundell, Etherton, Hammer, Liu, Powell, Südhof (bib48) 2007; 318
Calfa, Li, Rutherford, Pozzo-Miller (bib6) 2015; 25
Morales, Choi, Kirkwood (bib36) 2002; 22
Antoine, Langberg, Schnepel, Feldman (bib2) 2019; 101
Han, Tai, Westenbroek, Yu, Cheah, Potter, Rubenstein, Scheuer, de la Iglesia, Catterall (bib25) 2012; 489
Denève, Alemi, Bourdoukan (bib16) 2017; 94
Nelson, Valakh (bib39) 2015; 87
Anticevic, Lisman (bib1) 2017; 81
Choy, Agahari, Li, Stricker (bib9) 2018; 12
Ferguson, Gao (bib19) 2018; 12
Vogels, Sprekeler, Zenke, Clopath, Gerstner (bib54) 2011
Xue, Atallah, Scanziani (bib58) 2014; 511
Nanou, Catterall (bib38) 2018; 98
Vyazovskiy, Cirelli, Pfister-Genskow, Faraguna, Tononi (bib55) 2008; 11
Judson, Wallace, Sidorov, Burette, Gu, van Woerden, King, Han, Zylka, Elgersma (bib29) 2016; 90
Cilz, Lei (bib10) 2017; 27
Shen, McKeown, Demas, Cline (bib46) 2011; 106
Wallace, Burette, Weinberg, Philpot (bib56) 2012; 74
Steele, Mauk (bib47) 1999
Zhou, Liang, Xiong, Li, Li, Xiao, Tao, Zhang (bib60) 2014; 17
Gilestro, Tononi, Cirelli (bib23) 2009; 324
Liu, Faraguna, Cirelli, Tononi, Gao (bib33) 2010; 30
Rotaru, van Woerden, Wallaard, Elgersma (bib43) 2018; 38
Froemke (bib21) 2015; 38
Hanlon, Tasali, Leproult, Stuhr, Doncheck, de Wit, Hillard, Van Cauter (bib27) 2016; 39
de Vivo, Bellesi, Marshall, Bushong, Ellisman, Tononi, Cirelli (bib14) 2017; 355
Bateup, Johnson, Denefrio, Saulnier, Kornacker, Sabatini (bib3) 2013; 78
D’amour, Froemke (bib12) 2015; 86
Jurgensen, Castillo (bib30) 2015; 35
Busche, Kekuš, Adelsberger, Noda, Förstl, Nelken, Konnerth (bib5) 2015; 18
Murillo-Rodriguez, Désarnaud, Prospéro-García (bib37) 2006; 79
Dani, Chang, Maffei, Turrigiano, Jaenisch, Nelson (bib13) 2005; 102
Madison, Nicoll (bib34) 1988; 442
Han, Tai, Jones, Scheuer, Catterall (bib26) 2014; 81
Keck, Hübener, Bonhoeffer (bib31) 2017; 43
Laperchia, Imperatore, Azeez, Del Gallo, Bertini, Grassi-Zucconi, Cristino, Bentivoglio (bib32) 2017; 222
Niethard, Hasegawa, Itokazu, Oyanedel, Born, Sato (bib40) 2016; 26
Cirelli, Gutierrez, Tononi (bib11) 2004; 41
Faradji-Prevautel, Cespuglio, Jouvet (bib18) 1990; 526
Gkogkas, Khoutorsky, Ran, Rampakakis, Nevarko, Weatherill, Vasuta, Yee, Truitt, Dallaire (bib24) 2013; 493
Rosenberg, Patterson, Angelaki (bib42) 2015; 112
Maret, Faraguna, Nelson, Cirelli, Tononi (bib35) 2011; 14
Yizhar, Fenno, Prigge, Schneider, Davidson, O’Shea, Sohal, Goshen, Finkelstein, Paz (bib59) 2011; 477
Fortin, Trettel, Levine (bib20) 2004; 92
Carandini, Heeger (bib7) 2011; 13
Del Cid-Pellitero, Plavski, Mainville, Jones (bib15) 2017; 11
Tononi, Cirelli (bib61) 2014; 81
He, Huertas, Hong, Tie, Hell, Shouval, Kirkwood (bib62) 2015; 88
Laperchia (10.1016/j.neuron.2019.11.011_bib32) 2017; 222
Rotaru (10.1016/j.neuron.2019.11.011_bib43) 2018; 38
Judson (10.1016/j.neuron.2019.11.011_bib29) 2016; 90
Cilz (10.1016/j.neuron.2019.11.011_bib10) 2017; 27
Fortin (10.1016/j.neuron.2019.11.011_bib20) 2004; 92
Gilestro (10.1016/j.neuron.2019.11.011_bib23) 2009; 324
D’amour (10.1016/j.neuron.2019.11.011_bib12) 2015; 86
Han (10.1016/j.neuron.2019.11.011_bib26) 2014; 81
Tononi (10.1016/j.neuron.2019.11.011_bib61) 2014; 81
Trettel (10.1016/j.neuron.2019.11.011_bib51) 2004; 556
Nelson (10.1016/j.neuron.2019.11.011_bib39) 2015; 87
Yizhar (10.1016/j.neuron.2019.11.011_bib59) 2011; 477
Gao (10.1016/j.neuron.2019.11.011_bib22) 2017; 372
Zhou (10.1016/j.neuron.2019.11.011_bib60) 2014; 17
Calfa (10.1016/j.neuron.2019.11.011_bib6) 2015; 25
Diering (10.1016/j.neuron.2019.11.011_bib17) 2017; 355
Faradji-Prevautel (10.1016/j.neuron.2019.11.011_bib18) 1990; 526
Steele (10.1016/j.neuron.2019.11.011_bib47) 1999; 81
Tu (10.1016/j.neuron.2019.11.011_bib52) 2017; 14
Petrus (10.1016/j.neuron.2019.11.011_bib41) 2015; 35
Cirelli (10.1016/j.neuron.2019.11.011_bib11) 2004; 41
Del Cid-Pellitero (10.1016/j.neuron.2019.11.011_bib15) 2017; 11
Liu (10.1016/j.neuron.2019.11.011_bib33) 2010; 30
Wallace (10.1016/j.neuron.2019.11.011_bib56) 2012; 74
de Vivo (10.1016/j.neuron.2019.11.011_bib14) 2017; 355
Nanou (10.1016/j.neuron.2019.11.011_bib38) 2018; 98
Ferguson (10.1016/j.neuron.2019.11.011_bib19) 2018; 12
Niethard (10.1016/j.neuron.2019.11.011_bib40) 2016; 26
Chellappa (10.1016/j.neuron.2019.11.011_bib8) 2016; 6
Rubin (10.1016/j.neuron.2019.11.011_bib44) 2017; 114
Anticevic (10.1016/j.neuron.2019.11.011_bib1) 2017; 81
Gkogkas (10.1016/j.neuron.2019.11.011_bib24) 2013; 493
Maret (10.1016/j.neuron.2019.11.011_bib35) 2011; 14
Xue (10.1016/j.neuron.2019.11.011_bib58) 2014; 511
Tao (10.1016/j.neuron.2019.11.011_bib49) 2005; 45
Froemke (10.1016/j.neuron.2019.11.011_bib21) 2015; 38
Choy (10.1016/j.neuron.2019.11.011_bib9) 2018; 12
Rosenberg (10.1016/j.neuron.2019.11.011_bib42) 2015; 112
Isaacson (10.1016/j.neuron.2019.11.011_bib28) 2011; 72
Madison (10.1016/j.neuron.2019.11.011_bib34) 1988; 442
Dani (10.1016/j.neuron.2019.11.011_bib13) 2005; 102
He (10.1016/j.neuron.2019.11.011_bib62) 2015; 88
Murillo-Rodriguez (10.1016/j.neuron.2019.11.011_bib37) 2006; 79
Tabuchi (10.1016/j.neuron.2019.11.011_bib48) 2007; 318
Han (10.1016/j.neuron.2019.11.011_bib25) 2012; 489
Trettel (10.1016/j.neuron.2019.11.011_bib50) 2003; 89
Valenti (10.1016/j.neuron.2019.11.011_bib53) 2004; 61
Vyazovskiy (10.1016/j.neuron.2019.11.011_bib55) 2008; 11
Sadowski (10.1016/j.neuron.2019.11.011_bib45) 2016; 14
Shen (10.1016/j.neuron.2019.11.011_bib46) 2011; 106
Busche (10.1016/j.neuron.2019.11.011_bib5) 2015; 18
Denève (10.1016/j.neuron.2019.11.011_bib16) 2017; 94
Busche (10.1016/j.neuron.2019.11.011_bib4) 2016; 371
Carandini (10.1016/j.neuron.2019.11.011_bib7) 2011; 13
Keck (10.1016/j.neuron.2019.11.011_bib31) 2017; 43
Antoine (10.1016/j.neuron.2019.11.011_bib2) 2019; 101
Bateup (10.1016/j.neuron.2019.11.011_bib3) 2013; 78
Vogels (10.1016/j.neuron.2019.11.011_bib54) 2011; 334
Hanlon (10.1016/j.neuron.2019.11.011_bib27) 2016; 39
Jurgensen (10.1016/j.neuron.2019.11.011_bib30) 2015; 35
Morales (10.1016/j.neuron.2019.11.011_bib36) 2002; 22
32078790 - Neuron. 2020 Feb 19;105(4):589-591
References_xml – volume: 38
  start-page: 195
  year: 2015
  end-page: 219
  ident: bib21
  article-title: Plasticity of cortical excitatory-inhibitory balance
  publication-title: Annu. Rev. Neurosci.
– volume: 101
  start-page: 648
  year: 2019
  end-page: 661.e4
  ident: bib2
  article-title: Increased excitation-inhibition ratio stabilizes synapse and circuit excitability in four autism mouse models
  publication-title: Neuron
– volume: 22
  start-page: 8084
  year: 2002
  end-page: 8090
  ident: bib36
  article-title: Dark rearing alters the development of GABAergic transmission in visual cortex
  publication-title: J. Neurosci.
– volume: 556
  start-page: 95
  year: 2004
  end-page: 107
  ident: bib51
  article-title: Endocannabinoid signalling selectively targets perisomatic inhibitory inputs to pyramidal neurones in juvenile mouse neocortex
  publication-title: J. Physiol.
– volume: 114
  start-page: E9366
  year: 2017
  end-page: E9375
  ident: bib44
  article-title: Balanced excitation and inhibition are required for high-capacity, noise-robust neuronal selectivity
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 17
  start-page: 841
  year: 2014
  end-page: 850
  ident: bib60
  article-title: Scaling down of balanced excitation and inhibition by active behavioral states in auditory cortex
  publication-title: Nat. Neurosci.
– start-page: 1559
  year: 1999
  end-page: 1566
  ident: bib47
  article-title: Inhibitory control of LTP and LTD: stability of synapse strength J
  publication-title: Neurophysiol.
– volume: 30
  start-page: 8671
  year: 2010
  end-page: 8675
  ident: bib33
  article-title: Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex
  publication-title: J. Neurosci.
– volume: 43
  start-page: 87
  year: 2017
  end-page: 93
  ident: bib31
  article-title: Interactions between synaptic homeostatic mechanisms: an attempt to reconcile BCM theory, synaptic scaling, and changing excitation/inhibition balance
  publication-title: Curr. Opin. Neurobiol.
– volume: 6
  start-page: 33661
  year: 2016
  ident: bib8
  article-title: Circadian dynamics in measures of cortical excitation and inhibition balance
  publication-title: Sci. Rep.
– volume: 45
  start-page: 829
  year: 2005
  end-page: 836
  ident: bib49
  article-title: Activity-dependent matching of excitatory and inhibitory inputs during refinement of visual receptive fields
  publication-title: Neuron
– volume: 61
  start-page: 945
  year: 2004
  end-page: 950
  ident: bib53
  article-title: Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain
  publication-title: Cell. Mol. Life Sci.
– volume: 18
  start-page: 1623
  year: 2015
  end-page: 1630
  ident: bib5
  article-title: Rescue of long-range circuit dysfunction in Alzheimer’s disease models
  publication-title: Nat. Neurosci.
– volume: 442
  start-page: 131
  year: 1988
  end-page: 138
  ident: bib34
  article-title: Norepinephrine decreases synaptic inhibition in the rat hippocampus
  publication-title: Brain Res.
– volume: 14
  start-page: 1418
  year: 2011
  end-page: 1420
  ident: bib35
  article-title: Sleep and waking modulate spine turnover in the adolescent mouse cortex
  publication-title: Nat. Neurosci.
– volume: 106
  start-page: 2285
  year: 2011
  end-page: 2302
  ident: bib46
  article-title: Inhibition to excitation ratio regulates visual system responses and behavior in vivo
  publication-title: J. Neurophysiol.
– volume: 94
  start-page: 969
  year: 2017
  end-page: 977
  ident: bib16
  article-title: The brain as an efficient and robust adaptive learner
  publication-title: Neuron
– volume: 25
  start-page: 159
  year: 2015
  end-page: 168
  ident: bib6
  article-title: Excitation/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 of Mecp2 knockout mice
  publication-title: Hippocampus
– start-page: 1569
  year: 2011
  end-page: 1573
  ident: bib54
  article-title: Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks
  publication-title: Science
– volume: 81
  start-page: 818
  year: 2017
  end-page: 820
  ident: bib1
  article-title: How can global alteration of excitation/inhibition balance lead to the local dysfunctions that underlie schizophrenia?
  publication-title: Biol. Psychiatry
– volume: 27
  start-page: 613
  year: 2017
  end-page: 631
  ident: bib10
  article-title: Histamine facilitates GABAergic transmission in the rat entorhinal cortex: roles of H
  publication-title: Hippocampus
– volume: 89
  start-page: 2334
  year: 2003
  end-page: 2338
  ident: bib50
  article-title: Endocannabinoids mediate rapid retrograde signaling at interneuron right-arrow pyramidal neuron synapses of the neocortex
  publication-title: J. Neurophysiol.
– volume: 41
  start-page: 35
  year: 2004
  end-page: 43
  ident: bib11
  article-title: Extensive and divergent effects of sleep and wakefulness on brain gene expression
  publication-title: Neuron
– volume: 372
  year: 2017
  ident: bib22
  article-title: Experience-dependent homeostasis of ‘noise’ at inhibitory synapses preserves information coding in adult visual cortex
  publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci.
– volume: 90
  start-page: 56
  year: 2016
  end-page: 69
  ident: bib29
  article-title: GABAergic neuron-specific loss of Ube3a causes Angelman syndrome-like EEG abnormalities and enhances seizure susceptibility
  publication-title: Neuron
– volume: 14
  start-page: 1916
  year: 2016
  end-page: 1929
  ident: bib45
  article-title: Sharp-wave ripples orchestrate the induction of synaptic plasticity during reactivation of place cell firing patterns in the hippocampus
  publication-title: Cell Rep.
– volume: 72
  start-page: 231
  year: 2011
  end-page: 243
  ident: bib28
  article-title: How inhibition shapes cortical activity
  publication-title: Neuron
– volume: 355
  start-page: 511
  year: 2017
  end-page: 515
  ident: bib17
  article-title: Homer1a drives homeostatic scaling-down of excitatory synapses during sleep
  publication-title: Science
– volume: 74
  start-page: 793
  year: 2012
  end-page: 800
  ident: bib56
  article-title: Maternal loss of Ube3a produces an excitatory/inhibitory imbalance through neuron type-specific synaptic defects
  publication-title: Neuron
– volume: 355
  start-page: 507
  year: 2017
  end-page: 510
  ident: bib14
  article-title: Ultrastructural evidence for synaptic scaling across the wake/sleep cycle
  publication-title: Science
– volume: 371
  start-page: 20150429
  year: 2016
  ident: bib4
  article-title: Impairments of neural circuit function in Alzheimer’s disease
  publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci.
– volume: 35
  start-page: 8790
  year: 2015
  end-page: 8801
  ident: bib41
  article-title: Vision loss shifts the balance of feedforward and intracortical circuits in opposite directions in mouse primary auditory and visual cortices
  publication-title: J. Neurosci.
– volume: 39
  start-page: 653
  year: 2016
  end-page: 664
  ident: bib27
  article-title: Sleep restriction enhances the daily rhythm of circulating levels of endocannabinoid 2-arachidonoylglycerol
  publication-title: Sleep (Basel)
– volume: 78
  start-page: 510
  year: 2013
  end-page: 522
  ident: bib3
  article-title: Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis
  publication-title: Neuron
– volume: 79
  start-page: 30
  year: 2006
  end-page: 37
  ident: bib37
  article-title: Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat
  publication-title: Life Sci.
– volume: 324
  start-page: 109
  year: 2009
  end-page: 112
  ident: bib23
  article-title: Widespread changes in synaptic markers as a function of sleep and wakefulness in
  publication-title: Science
– volume: 38
  start-page: 8011
  year: 2018
  end-page: 8030
  ident: bib43
  article-title: Adult
  publication-title: J. Neurosci.
– volume: 489
  start-page: 385
  year: 2012
  end-page: 390
  ident: bib25
  article-title: Autistic behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission
  publication-title: Nature
– volume: 92
  start-page: 2105
  year: 2004
  end-page: 2112
  ident: bib20
  article-title: Brief trains of action potentials enhance pyramidal neuron excitability via endocannabinoid-mediated suppression of inhibition
  publication-title: J. Neurophysiol.
– volume: 11
  start-page: 17
  year: 2017
  ident: bib15
  article-title: Homeostatic changes in GABA and glutamate receptors on excitatory cortical neurons during sleep deprivation and recovery
  publication-title: Front. Syst. Neurosci.
– volume: 12
  start-page: 37
  year: 2018
  ident: bib19
  article-title: PV interneurons: critical regulators of E/I balance for prefrontal cortex-dependent behavior and psychiatric disorders
  publication-title: Front. Neural Circuits
– volume: 112
  start-page: 9158
  year: 2015
  end-page: 9165
  ident: bib42
  article-title: A computational perspective on autism
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 511
  start-page: 596
  year: 2014
  end-page: 600
  ident: bib58
  article-title: Equalizing excitation-inhibition ratios across visual cortical neurons
  publication-title: Nature
– volume: 81
  start-page: 12
  year: 2014
  end-page: 34
  ident: bib61
  article-title: Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration
  publication-title: Neuron
– volume: 35
  start-page: 14681
  year: 2015
  end-page: 14687
  ident: bib30
  article-title: Selective dysregulation of hippocampal inhibition in the mouse lacking autism candidate gene CNTNAP2
  publication-title: J. Neurosci.
– volume: 26
  start-page: 2739
  year: 2016
  end-page: 2749
  ident: bib40
  article-title: Sleep-stage-specific regulation of cortical excitation and inhibition
  publication-title: Curr. Biol.
– volume: 87
  start-page: 684
  year: 2015
  end-page: 698
  ident: bib39
  article-title: Excitatory/inhibitory balance and circuit homeostasis in autism spectrum disorders
  publication-title: Neuron
– volume: 81
  start-page: 1282
  year: 2014
  end-page: 1289
  ident: bib26
  article-title: Enhancement of inhibitory neurotransmission by GABAA receptors having α2,3-subunits ameliorates behavioral deficits in a mouse model of autism
  publication-title: Neuron
– volume: 98
  start-page: 466
  year: 2018
  end-page: 481
  ident: bib38
  article-title: Calcium channels, synaptic plasticity, and neuropsychiatric disease
  publication-title: Neuron
– volume: 11
  start-page: 200
  year: 2008
  end-page: 208
  ident: bib55
  article-title: Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
  publication-title: Nat. Neurosci.
– volume: 477
  start-page: 171
  year: 2011
  end-page: 178
  ident: bib59
  article-title: Neocortical excitation/inhibition balance in information processing and social dysfunction
  publication-title: Nature
– volume: 493
  start-page: 371
  year: 2013
  end-page: 377
  ident: bib24
  article-title: Autism-related deficits via dysregulated eIF4E-dependent translational control
  publication-title: Nature
– volume: 88
  start-page: 528
  year: 2015
  end-page: 538
  ident: bib62
  article-title: Distinct Eligibility Traces for LTP and LTD in Cortical Synpases
  publication-title: Neuron
– volume: 526
  start-page: 207
  year: 1990
  end-page: 216
  ident: bib18
  article-title: Circadian rest-activity rhythms in the anophthalmic, monocular and binocular ZRDCT/An mice. Retinal and serotoninergic (raphe) influences
  publication-title: Brain Res.
– volume: 222
  start-page: 3847
  year: 2017
  end-page: 3859
  ident: bib32
  article-title: The excitatory/inhibitory input to orexin/hypocretin neuron soma undergoes day/night reorganization
  publication-title: Brain Struct. Funct.
– volume: 13
  start-page: 51
  year: 2011
  end-page: 62
  ident: bib7
  article-title: Normalization as a canonical neural computation
  publication-title: Nat. Rev. Neurosci.
– volume: 86
  start-page: 514
  year: 2015
  end-page: 528
  ident: bib12
  article-title: Inhibitory and excitatory spike-timing-dependent plasticity in the auditory cortex
  publication-title: Neuron
– volume: 102
  start-page: 12560
  year: 2005
  end-page: 12565
  ident: bib13
  article-title: Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 318
  start-page: 71
  year: 2007
  end-page: 76
  ident: bib48
  article-title: A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice
  publication-title: Science
– volume: 12
  start-page: 213
  year: 2018
  ident: bib9
  article-title: Noradrenaline increases mEPSC frequency in pyramidal cells in layer II of rat barrel cortex via calcium release from presynaptic stores
  publication-title: Front. Cell. Neurosci.
– volume: 14
  start-page: 5
  year: 2017
  ident: bib52
  article-title: Absolute quantitative lipidomics reveals lipidome-wide alterations in aging brain
  publication-title: Metabolomics
– volume: 6
  start-page: 33661
  year: 2016
  ident: 10.1016/j.neuron.2019.11.011_bib8
  article-title: Circadian dynamics in measures of cortical excitation and inhibition balance
  publication-title: Sci. Rep.
  doi: 10.1038/srep33661
– volume: 26
  start-page: 2739
  year: 2016
  ident: 10.1016/j.neuron.2019.11.011_bib40
  article-title: Sleep-stage-specific regulation of cortical excitation and inhibition
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2016.08.035
– volume: 11
  start-page: 17
  year: 2017
  ident: 10.1016/j.neuron.2019.11.011_bib15
  article-title: Homeostatic changes in GABA and glutamate receptors on excitatory cortical neurons during sleep deprivation and recovery
  publication-title: Front. Syst. Neurosci.
  doi: 10.3389/fnsys.2017.00017
– volume: 45
  start-page: 829
  year: 2005
  ident: 10.1016/j.neuron.2019.11.011_bib49
  article-title: Activity-dependent matching of excitatory and inhibitory inputs during refinement of visual receptive fields
  publication-title: Neuron
  doi: 10.1016/j.neuron.2005.01.046
– volume: 18
  start-page: 1623
  year: 2015
  ident: 10.1016/j.neuron.2019.11.011_bib5
  article-title: Rescue of long-range circuit dysfunction in Alzheimer’s disease models
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4137
– volume: 12
  start-page: 37
  year: 2018
  ident: 10.1016/j.neuron.2019.11.011_bib19
  article-title: PV interneurons: critical regulators of E/I balance for prefrontal cortex-dependent behavior and psychiatric disorders
  publication-title: Front. Neural Circuits
  doi: 10.3389/fncir.2018.00037
– volume: 17
  start-page: 841
  year: 2014
  ident: 10.1016/j.neuron.2019.11.011_bib60
  article-title: Scaling down of balanced excitation and inhibition by active behavioral states in auditory cortex
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.3701
– volume: 43
  start-page: 87
  year: 2017
  ident: 10.1016/j.neuron.2019.11.011_bib31
  article-title: Interactions between synaptic homeostatic mechanisms: an attempt to reconcile BCM theory, synaptic scaling, and changing excitation/inhibition balance
  publication-title: Curr. Opin. Neurobiol.
  doi: 10.1016/j.conb.2017.02.003
– volume: 102
  start-page: 12560
  year: 2005
  ident: 10.1016/j.neuron.2019.11.011_bib13
  article-title: Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0506071102
– volume: 11
  start-page: 200
  year: 2008
  ident: 10.1016/j.neuron.2019.11.011_bib55
  article-title: Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn2035
– volume: 526
  start-page: 207
  year: 1990
  ident: 10.1016/j.neuron.2019.11.011_bib18
  article-title: Circadian rest-activity rhythms in the anophthalmic, monocular and binocular ZRDCT/An mice. Retinal and serotoninergic (raphe) influences
  publication-title: Brain Res.
  doi: 10.1016/0006-8993(90)91223-4
– volume: 61
  start-page: 945
  year: 2004
  ident: 10.1016/j.neuron.2019.11.011_bib53
  article-title: Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-003-3453-5
– volume: 13
  start-page: 51
  year: 2011
  ident: 10.1016/j.neuron.2019.11.011_bib7
  article-title: Normalization as a canonical neural computation
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn3136
– volume: 324
  start-page: 109
  year: 2009
  ident: 10.1016/j.neuron.2019.11.011_bib23
  article-title: Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila
  publication-title: Science
  doi: 10.1126/science.1166673
– volume: 114
  start-page: E9366
  year: 2017
  ident: 10.1016/j.neuron.2019.11.011_bib44
  article-title: Balanced excitation and inhibition are required for high-capacity, noise-robust neuronal selectivity
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1705841114
– volume: 78
  start-page: 510
  year: 2013
  ident: 10.1016/j.neuron.2019.11.011_bib3
  article-title: Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.03.017
– volume: 101
  start-page: 648
  year: 2019
  ident: 10.1016/j.neuron.2019.11.011_bib2
  article-title: Increased excitation-inhibition ratio stabilizes synapse and circuit excitability in four autism mouse models
  publication-title: Neuron
  doi: 10.1016/j.neuron.2018.12.026
– volume: 30
  start-page: 8671
  year: 2010
  ident: 10.1016/j.neuron.2019.11.011_bib33
  article-title: Direct evidence for wake-related increases and sleep-related decreases in synaptic strength in rodent cortex
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1409-10.2010
– volume: 372
  year: 2017
  ident: 10.1016/j.neuron.2019.11.011_bib22
  article-title: Experience-dependent homeostasis of ‘noise’ at inhibitory synapses preserves information coding in adult visual cortex
  publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci.
  doi: 10.1098/rstb.2016.0156
– volume: 12
  start-page: 213
  year: 2018
  ident: 10.1016/j.neuron.2019.11.011_bib9
  article-title: Noradrenaline increases mEPSC frequency in pyramidal cells in layer II of rat barrel cortex via calcium release from presynaptic stores
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2018.00213
– volume: 14
  start-page: 1916
  year: 2016
  ident: 10.1016/j.neuron.2019.11.011_bib45
  article-title: Sharp-wave ripples orchestrate the induction of synaptic plasticity during reactivation of place cell firing patterns in the hippocampus
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2016.01.061
– volume: 81
  start-page: 818
  year: 2017
  ident: 10.1016/j.neuron.2019.11.011_bib1
  article-title: How can global alteration of excitation/inhibition balance lead to the local dysfunctions that underlie schizophrenia?
  publication-title: Biol. Psychiatry
  doi: 10.1016/j.biopsych.2016.12.006
– volume: 106
  start-page: 2285
  year: 2011
  ident: 10.1016/j.neuron.2019.11.011_bib46
  article-title: Inhibition to excitation ratio regulates visual system responses and behavior in vivo
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.00641.2011
– volume: 112
  start-page: 9158
  year: 2015
  ident: 10.1016/j.neuron.2019.11.011_bib42
  article-title: A computational perspective on autism
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1510583112
– volume: 334
  start-page: 1569
  year: 2011
  ident: 10.1016/j.neuron.2019.11.011_bib54
  article-title: Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks
  publication-title: Science
  doi: 10.1126/science.1211095
– volume: 493
  start-page: 371
  year: 2013
  ident: 10.1016/j.neuron.2019.11.011_bib24
  article-title: Autism-related deficits via dysregulated eIF4E-dependent translational control
  publication-title: Nature
  doi: 10.1038/nature11628
– volume: 38
  start-page: 195
  year: 2015
  ident: 10.1016/j.neuron.2019.11.011_bib21
  article-title: Plasticity of cortical excitatory-inhibitory balance
  publication-title: Annu. Rev. Neurosci.
  doi: 10.1146/annurev-neuro-071714-034002
– volume: 90
  start-page: 56
  year: 2016
  ident: 10.1016/j.neuron.2019.11.011_bib29
  article-title: GABAergic neuron-specific loss of Ube3a causes Angelman syndrome-like EEG abnormalities and enhances seizure susceptibility
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.02.040
– volume: 94
  start-page: 969
  year: 2017
  ident: 10.1016/j.neuron.2019.11.011_bib16
  article-title: The brain as an efficient and robust adaptive learner
  publication-title: Neuron
  doi: 10.1016/j.neuron.2017.05.016
– volume: 556
  start-page: 95
  year: 2004
  ident: 10.1016/j.neuron.2019.11.011_bib51
  article-title: Endocannabinoid signalling selectively targets perisomatic inhibitory inputs to pyramidal neurones in juvenile mouse neocortex
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2003.058198
– volume: 86
  start-page: 514
  year: 2015
  ident: 10.1016/j.neuron.2019.11.011_bib12
  article-title: Inhibitory and excitatory spike-timing-dependent plasticity in the auditory cortex
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.03.014
– volume: 81
  start-page: 1282
  year: 2014
  ident: 10.1016/j.neuron.2019.11.011_bib26
  article-title: Enhancement of inhibitory neurotransmission by GABAA receptors having α2,3-subunits ameliorates behavioral deficits in a mouse model of autism
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.01.016
– volume: 41
  start-page: 35
  year: 2004
  ident: 10.1016/j.neuron.2019.11.011_bib11
  article-title: Extensive and divergent effects of sleep and wakefulness on brain gene expression
  publication-title: Neuron
  doi: 10.1016/S0896-6273(03)00814-6
– volume: 511
  start-page: 596
  year: 2014
  ident: 10.1016/j.neuron.2019.11.011_bib58
  article-title: Equalizing excitation-inhibition ratios across visual cortical neurons
  publication-title: Nature
  doi: 10.1038/nature13321
– volume: 477
  start-page: 171
  year: 2011
  ident: 10.1016/j.neuron.2019.11.011_bib59
  article-title: Neocortical excitation/inhibition balance in information processing and social dysfunction
  publication-title: Nature
  doi: 10.1038/nature10360
– volume: 92
  start-page: 2105
  year: 2004
  ident: 10.1016/j.neuron.2019.11.011_bib20
  article-title: Brief trains of action potentials enhance pyramidal neuron excitability via endocannabinoid-mediated suppression of inhibition
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.00351.2004
– volume: 318
  start-page: 71
  year: 2007
  ident: 10.1016/j.neuron.2019.11.011_bib48
  article-title: A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice
  publication-title: Science
  doi: 10.1126/science.1146221
– volume: 35
  start-page: 8790
  year: 2015
  ident: 10.1016/j.neuron.2019.11.011_bib41
  article-title: Vision loss shifts the balance of feedforward and intracortical circuits in opposite directions in mouse primary auditory and visual cortices
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4975-14.2015
– volume: 87
  start-page: 684
  year: 2015
  ident: 10.1016/j.neuron.2019.11.011_bib39
  article-title: Excitatory/inhibitory balance and circuit homeostasis in autism spectrum disorders
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.07.033
– volume: 371
  start-page: 20150429
  year: 2016
  ident: 10.1016/j.neuron.2019.11.011_bib4
  article-title: Impairments of neural circuit function in Alzheimer’s disease
  publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci.
  doi: 10.1098/rstb.2015.0429
– volume: 25
  start-page: 159
  year: 2015
  ident: 10.1016/j.neuron.2019.11.011_bib6
  article-title: Excitation/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 of Mecp2 knockout mice
  publication-title: Hippocampus
  doi: 10.1002/hipo.22360
– volume: 39
  start-page: 653
  year: 2016
  ident: 10.1016/j.neuron.2019.11.011_bib27
  article-title: Sleep restriction enhances the daily rhythm of circulating levels of endocannabinoid 2-arachidonoylglycerol
  publication-title: Sleep (Basel)
  doi: 10.5665/sleep.5546
– volume: 88
  start-page: 528
  year: 2015
  ident: 10.1016/j.neuron.2019.11.011_bib62
  article-title: Distinct Eligibility Traces for LTP and LTD in Cortical Synpases
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.09.037
– volume: 355
  start-page: 507
  year: 2017
  ident: 10.1016/j.neuron.2019.11.011_bib14
  article-title: Ultrastructural evidence for synaptic scaling across the wake/sleep cycle
  publication-title: Science
  doi: 10.1126/science.aah5982
– volume: 489
  start-page: 385
  year: 2012
  ident: 10.1016/j.neuron.2019.11.011_bib25
  article-title: Autistic behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission
  publication-title: Nature
  doi: 10.1038/nature11356
– volume: 442
  start-page: 131
  year: 1988
  ident: 10.1016/j.neuron.2019.11.011_bib34
  article-title: Norepinephrine decreases synaptic inhibition in the rat hippocampus
  publication-title: Brain Res.
  doi: 10.1016/0006-8993(88)91440-0
– volume: 81
  start-page: 1559
  year: 1999
  ident: 10.1016/j.neuron.2019.11.011_bib47
  article-title: Inhibitory control of LTP and LTD: stability of synapse strength J
  publication-title: Neurophysiol.
  doi: 10.1152/jn.1999.81.4.1559
– volume: 14
  start-page: 1418
  year: 2011
  ident: 10.1016/j.neuron.2019.11.011_bib35
  article-title: Sleep and waking modulate spine turnover in the adolescent mouse cortex
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2934
– volume: 98
  start-page: 466
  year: 2018
  ident: 10.1016/j.neuron.2019.11.011_bib38
  article-title: Calcium channels, synaptic plasticity, and neuropsychiatric disease
  publication-title: Neuron
  doi: 10.1016/j.neuron.2018.03.017
– volume: 79
  start-page: 30
  year: 2006
  ident: 10.1016/j.neuron.2019.11.011_bib37
  article-title: Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2005.12.028
– volume: 38
  start-page: 8011
  year: 2018
  ident: 10.1016/j.neuron.2019.11.011_bib43
  article-title: Adult Ube3a gene reinstatement restores the electrophysiological deficits of prefrontal cortex layer 5 neurons in a mouse model of Angelman syndrome
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0083-18.2018
– volume: 222
  start-page: 3847
  year: 2017
  ident: 10.1016/j.neuron.2019.11.011_bib32
  article-title: The excitatory/inhibitory input to orexin/hypocretin neuron soma undergoes day/night reorganization
  publication-title: Brain Struct. Funct.
  doi: 10.1007/s00429-017-1466-3
– volume: 27
  start-page: 613
  year: 2017
  ident: 10.1016/j.neuron.2019.11.011_bib10
  article-title: Histamine facilitates GABAergic transmission in the rat entorhinal cortex: roles of H1 and H2 receptors, Na+ -permeable cation channels, and inward rectifier K+ channels
  publication-title: Hippocampus
  doi: 10.1002/hipo.22718
– volume: 355
  start-page: 511
  year: 2017
  ident: 10.1016/j.neuron.2019.11.011_bib17
  article-title: Homer1a drives homeostatic scaling-down of excitatory synapses during sleep
  publication-title: Science
  doi: 10.1126/science.aai8355
– volume: 72
  start-page: 231
  year: 2011
  ident: 10.1016/j.neuron.2019.11.011_bib28
  article-title: How inhibition shapes cortical activity
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.09.027
– volume: 74
  start-page: 793
  year: 2012
  ident: 10.1016/j.neuron.2019.11.011_bib56
  article-title: Maternal loss of Ube3a produces an excitatory/inhibitory imbalance through neuron type-specific synaptic defects
  publication-title: Neuron
  doi: 10.1016/j.neuron.2012.03.036
– volume: 22
  start-page: 8084
  year: 2002
  ident: 10.1016/j.neuron.2019.11.011_bib36
  article-title: Dark rearing alters the development of GABAergic transmission in visual cortex
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.22-18-08084.2002
– volume: 35
  start-page: 14681
  year: 2015
  ident: 10.1016/j.neuron.2019.11.011_bib30
  article-title: Selective dysregulation of hippocampal inhibition in the mouse lacking autism candidate gene CNTNAP2
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1666-15.2015
– volume: 14
  start-page: 5
  year: 2017
  ident: 10.1016/j.neuron.2019.11.011_bib52
  article-title: Absolute quantitative lipidomics reveals lipidome-wide alterations in aging brain
  publication-title: Metabolomics
  doi: 10.1007/s11306-017-1304-x
– volume: 81
  start-page: 12
  year: 2014
  ident: 10.1016/j.neuron.2019.11.011_bib61
  article-title: Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.12.025
– volume: 89
  start-page: 2334
  year: 2003
  ident: 10.1016/j.neuron.2019.11.011_bib50
  article-title: Endocannabinoids mediate rapid retrograde signaling at interneuron right-arrow pyramidal neuron synapses of the neocortex
  publication-title: J. Neurophysiol.
  doi: 10.1152/jn.01037.2002
– reference: 32078790 - Neuron. 2020 Feb 19;105(4):589-591
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Snippet A balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical processing....
SummaryA balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical...
A dynamic balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical...
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SubjectTerms Animals
Circadian Rhythm - physiology
Circuits
Developmental stages
Excitatory Postsynaptic Potentials - physiology
Female
Hippocampus
Inhibitory Postsynaptic Potentials - physiology
Light
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nerve Net - cytology
Nerve Net - physiology
Neural Inhibition - physiology
Neurological diseases
Organ Culture Techniques
Pyramidal cells
Pyramidal Cells - physiology
Sleep
Visual cortex
Visual Cortex - cytology
Visual Cortex - physiology
Visual pathways
Visual Pathways - cytology
Visual Pathways - physiology
Title Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits
URI https://dx.doi.org/10.1016/j.neuron.2019.11.011
https://www.ncbi.nlm.nih.gov/pubmed/31831331
https://www.proquest.com/docview/2425658908
https://www.proquest.com/docview/2337002878
https://pubmed.ncbi.nlm.nih.gov/PMC9520672
Volume 105
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