Inflammation and Cancer: Triggers, Mechanisms, and Consequences

• Published in: Immunity (Cambridge, Mass.) Vol. 51; no. 1; pp. 27 - 41
• Main Authors: Greten, Florian R., Grivennikov, Sergei I.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16.07.2019; Elsevier Limited
• Subjects: Animals; Autoimmunity; Biology; Cancer; Cancer therapies; Carcinogenesis; cell plasticity; Chronic Disease; cytokine; Gene expression; Higher education; Homeostasis; Humans; Immune system; Immunity; Immunology; Immunotherapy; Infections - immunology; Inflammation; Lymphocytes; mechanisms; Medical prognosis; Metastases; Metastasis; Neoplasms - immunology; Neovascularization, Pathologic; Phenotypic plasticity; Roles; Signal transduction; Tissue engineering; Tumor Microenvironment; tumor progression; Tumorigenesis; Tumors; Vaccines; Wound Healing; cytokine; tumor progression; inflammation; metastasis; cancer; tumor microenvironment; cell plasticity; mechanisms

Inflammation predisposes to the development of cancer and promotes all stages of tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage in well-orchestrated reciprocal interactions to form an inflammatory tumor microenvironment (TME). Cells within the TME are high...