B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells

• Published in: Immunity (Cambridge, Mass.) Vol. 48; no. 2; pp. 313 - 326.e5
• Main Authors: Luo, Wei, Weisel, Florian, Shlomchik, Mark J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.02.2018; Elsevier Limited
• Subjects: Affinity; affinity maturation; Akt; Animals; Antigens; B cell; B cell receptor; c-Myc protein; CD40; CD40 antigen; CD40 Antigens - physiology; Cell cycle; Cell survival; Clonal selection; Forkhead Box Protein O1 - physiology; Foxo1; FOXO1 protein; germinal center; Germinal Center - immunology; Germinal centers; Helper cells; Kinases; Ligands; Light; Lymphocyte receptors; Lymphocytes; Lymphocytes B; Lymphocytes T; MAP Kinase Signaling System - physiology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Myc; Myc protein; Neurons; NF-kappa B - physiology; NF-κB protein; Phosphatidylinositol 3-Kinases - physiology; Positive selection; Proto-Oncogene Proteins c-akt - physiology; Proto-Oncogene Proteins c-myc - biosynthesis; Receptors, Antigen, B-Cell - physiology; Reentry; Signal Transduction - physiology; Signaling; Survival; Syk; Syk Kinase - physiology; Transcription factors; B cell; CD40; Syk; Myc; affinity maturation; germinal center; Akt; B cell receptor; Foxo1

Positive selection of germinal center (GC) B cells is driven by B cell receptor (BCR) affinity and requires help from follicular T helper cells. The transcription factors c-Myc and Foxo1 are critical for GC B cell selection and survival. However, how different affinity-related signaling events contr...