Autophagy in inflammation, infection, and immunometabolism

• Published in: Immunity (Cambridge, Mass.) Vol. 54; no. 3; pp. 437 - 453
• Main Author: Deretic, Vojo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.03.2021; Elsevier Limited
• Subjects: Animals; Autoimmune diseases; Autoimmunity; Autophagy; Autophagy - immunology; Bacteria; Humans; Immune system; Immune System - metabolism; Immunity; Immunity, Innate; Infections; Infections - immunology; Inflammasomes; Inflammation; Inflammation - immunology; Innate immunity; Interferon; Kinases; Liver diseases; Lysosomes; Lysosomes - metabolism; Membranes; Metabolic disorders; Metabolism; Mitochondria; Neurodegeneration; Organelles; Pathogens; Phagocytosis; Proteins; Quality control; Salmonella; Signal Transduction

Autophagy is a quality-control, metabolic, and innate immunity process. Normative autophagy affects many cell types, including hematopoietic as well as non-hematopoietic, and promotes health in model organisms and humans. When autophagy is perturbed, this has repercussions on diseases with inflammat...