Alterations in functional connectivity of resting state networks during experimental endotoxemia – An exploratory study in healthy men

• Published in: Brain, behavior, and immunity Vol. 54; pp. 17 - 26
• Main Authors: Labrenz, Franziska, Wrede, Karsten, Forsting, Michael, Engler, Harald, Schedlowski, Manfred, Elsenbruch, Sigrid, Benson, Sven
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.05.2016
• Subjects: Adult; Allergy and Immunology; Brain - drug effects; Brain - metabolism; Brain - pathology; Brain Mapping - methods; Connectome - methods; Endotoxemia; Endotoxemia - chemically induced; Endotoxemia - metabolism; Endotoxemia - pathology; fMRI; Functional connectivity; Humans; Interleukin-6 - metabolism; Lipopolysaccharides - administration & dosage; LPS; Magnetic Resonance Imaging - methods; Male; Membrane Potentials - drug effects; Membrane Potentials - physiology; Oxygen - blood; Psychiatry; Resting state; Sickness behavior; Systemic inflammation; Functional connectivity; fMRI; Sickness behavior; Resting state; Systemic inflammation; Endotoxemia; LPS
• ISSN: 0889-1591; 1090-2139; 1090-2139
• DOI: 10.1016/j.bbi.2015.11.010

•We tested effects of experimental endotoxemia on resting state brain activity.•Resting-state brain activity is altered during systemic inflammation.•Connectivity between the thalamus and the default mode network was increased.•Connectivity emanating from amygdala, insula, and cingulate cortex was r...