Dynamic vaccine blocks relapse to compulsive intake of heroin

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 22; pp. 9036 - 9041
• Main Authors: Schlosburg, Joel E., Vendruscolo, Leandro F., Bremer, Paul T., Lockner, Jonathan W., Wade, Carrie L., Nunes, Ashlee A. K., Stowe, G. Neil, Edwards, Scott, Janda, Kim D., Koob, George F.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 28.05.2013; National Acad Sciences
• Subjects: Animals; Antibodies; Antibodies - immunology; Biological Sciences; Chromatography, Liquid; Drug therapy; Heroin; Heroin - blood; Heroin - immunology; Heroin - metabolism; Heroin dependence; Heroin Dependence - prevention & control; Male; Metabolites; Morphine; Morphine - immunology; Morphine - metabolism; Morphine Derivatives - blood; Morphine Derivatives - immunology; Morphine Derivatives - metabolism; Motivation; Opiates; Opioid analgesics; Pharmacology; Psychotropics; Rats; Rats, Wistar; Relapse; Rodents; Secondary Prevention; Self Administration; Tandem Mass Spectrometry; Vaccination; Vaccines; Vaccines - immunology; antinociception; progressive ratio; immunotherapy

Heroin addiction, a chronic relapsing disorder characterized by excessive drug taking and seeking, requires constant psychotherapeutic and pharmacotherapeutic interventions to minimize the potential for further abuse. Vaccine strategies against many drugs of abuse are being developed that generate a...