Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

• Published in: Immunity (Cambridge, Mass.) Vol. 53; no. 3; pp. 533 - 547.e7
• Main Authors: Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.09.2020; Elsevier Limited; Cell Press
• Subjects: Animals; Apoptosis; Apoptosis - immunology; Bacteria; Caspase 1 - deficiency; Caspase 1 - genetics; Caspase 12 - deficiency; Caspase 12 - genetics; Caspase 8 - genetics; caspase-1; caspase-11; Caspase-8; Caspases, Initiator - deficiency; Caspases, Initiator - genetics; Cell death; Crosstalk; Defects; Defense; Defense programs; effector caspases; Effectors; Fail safe systems; gasdermin D; Infections; Initiators; Intracellular; Investigations; Kinases; Macrophages; Macrophages - immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mortality; Necroptosis; Necroptosis - immunology; Pathogens; Phosphorylation; Protein-serine/threonine kinase; Pyroptosis; Pyroptosis - immunology; Receptor-Interacting Protein Serine-Threonine Kinases - deficiency; Receptor-Interacting Protein Serine-Threonine Kinases - genetics; Salmonella; Salmonella - immunology; Salmonella Infections - immunology; Typhoid; pyroptosis; Salmonella; caspase-8; cell death; gasdermin D; apoptosis; caspase-11; effector caspases; caspase-1; necroptosis

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during Salmonella infection, we infected mice and macrophages deficient for diverse combinations of caspases-1, -11, -12, and -8 and receptor interact...