Galactan induces macrophage M0 to M1 conversion to combat colon cancer

• Published in: Food Science and Technology Research Vol. 30; no. 1; pp. 75 - 82
• Main Authors: Meng, Yue, Yang, Guang, Ren, Ai, Qu, Yunhe, Wang, Xue, Mayo, Kevin H., Zhou, Yifa, Song, Chengcheng
• Format: Journal Article
• Language: English
• Published: Tsukuba Japanese Society for Food Science and Technology 2024; Japan Science and Technology Agency
• Subjects: antitumor effect; Bone marrow; Cantharellus cibarius; Colon cancer; Colorectal cancer; Cytotoxicity; galactan; Macrophages; NF-κB protein; Toll-like receptors; Tumor necrosis factor-α

A 3-O-methylated-galactan WCCP-N-b from Cantharellus cibarius polarizes RAW264.7 macrophages, bone marrow-derived macrophages (BMDMs), and peritoneal macrophages (PEMs) leading to enhanced secretion of cytokine TNF-α and subsequent cytotoxic effects on HCT116 and CT26 colon cancer cells. Investigati...